舒血宁注射液对急性脑梗死患者血浆内皮素和血液流变学指标的影响

Effect of Shuxuening Injection on Plasma Endothelin and Hemorheologic Indexes in Patients with Acute Cerebral Infarction

目的观察舒血宁注射液对急性脑梗死患者血浆内皮素和血液流变学指标的影响。方法选取医院2012年1月至2013年12月收治的300例急性脑梗死患者,随机分为对照组与治疗组,各150例。对照组患者给予溶栓、抗凝、保护脑细胞、降压等常规治疗,治疗组在此基础上加用舒血宁注射液。观察两组患者的临床疗效,检测血浆内皮素和血液流变学指标,记录药品不良反应。结果治疗组的总有效率为89.33%,明显高于对照组的76.67%,神经功能缺损评分下降幅度也大于对照组,差异均有统计学意义(P<0.05);治疗组患者血浆内皮素和血液流变学指标的改善程度优于对照组(P<0.05)。治疗过程中未见明显药品不良反应。结论舒血宁注射液治疗急性脑梗死能提高临床疗效,降低血浆内皮素水平并改善血液流变学指标,安全性高,值得临床推广。

Objective To observe the effect of Shuxuening Injection on plasma endothelin and hemorheologic indexes in the patients with acute cerebral infarction. Methods 300 cases of acute cerebral infarction in our hospital from January 2012 to December 2013 were selected and randomly divided into the control group and the treatment group,150 cases in each group. The control group was given the routine therapy of thrombolysis,anticoagulation,brain cell protection and reducing pressure,while on this basis the treatment group was added with Shuxuening Injection. The clinical effects after treatment were observed in the two groups. The plasma endothelin and the bemorbeologic indexes were detected. The drugs adverse reactions were recorded. Results The total effective rate in the treatment group was 89.33% ,which was significantly higher than 76.67% in the control group,moreover,the reduction of neural function impairment scores was greater than that in the control group,the differences showed the statistical significance（ P 〈 0.05）;the improvement degree of plasma endothelin and the hemorheologic indexes in the treatment group was superior to those in the control group with statistical difference（P 〈 0.05）. No obvious drug adverse reactions were found during the treatment process. Conclusion Shuxuening Injection for treating acute cerebral infarction can increase the clinical effect,decrease the plasma endothelin level,improve the hemorheologic indexes with high safety ,which is worthy of being clinically promoted.