期刊文献+

急性心肌梗死患者生长分化因子-15、心肌梗死标志物水平表达及其相关性研究 被引量:8

Serum growth differentiation factor-15 and creatine kinase MB,cardiac troponin I,myoglobin levels in patients with acute myocardial infarction
下载PDF
导出
摘要 目的研究急性心肌梗死(AMI)患者血浆生长分化因子-15(GDF-15)、心肌梗死三项[肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、肌红蛋白(Mb)]表达水平及其之间的关系。方法以116例AMI患者作为AMI组,分为2个亚组,其中ST段抬高型心肌梗死(STEMI亚组)58例,非ST段抬高型心肌梗死(NSTEMI亚组)58例,采用酶联免疫吸附试验(ELISA法)测定血GDF-15水平,采用荧光免疫定量法测定CK-MB、cTnI、Mb水平;并以106例健康查体者作为健康对照组进行比较。结果AMI组血GDF-15、CK-MB、cTnI、Mb水平较健康对照组均显著增高(P<0.01),其中STEMI亚组较NSTEMI亚组升高更明显(P<0.05)。相关分析显示GDF-15与CK-MB、cTnI、Mb均呈正相关(r=0.558、r=0.579、r=0.545,P<0.01)。结论在AMI发病过程中,血GDF-15、CK-MB、cTnI、Mb水平升高,且STEMI患者升高更明显。GDF-15与CK-MB、cTnI、Mb呈正相关,联合检测可能更有助于AMI的早期诊断和危险分层。 Objective To investigate the relationship between acute myocardial infarction (AMI) patients serum growth differentiation factor-15 ( GDF-15 ), the myocardial infarction three [ isoenzyme of creatine kinase ( CK-MB), troponin I (cTnI), myoglobin (Mb) ] expression. Methods 116 cases of AMI patients as AMI group, they were divided into 2 sub- groups, the ST segment elevation myocardial infarction (STEMI group) with 58 eases, non ST segment elevation myocardial infarction (NSTEMI) group with 58 cases, using enzyme-linked immunosorbent assay (ELISA method) to determine the ser- um GDF-15 level, CK-MB, cTnI, Mb levels were determined using fluorescence immunoassay method; and 106 healthy sub- jects as healthy controls were compared. Results AMI group'sGDF-15, CK-MB, cTnI, Mb levels were increased than health- y control group significantly ( P 〈 0.01 ), where STEMI sub group were increased obviously than in NSTEMI group ( P 〈 0. 05). Correlation analysis showed that GDF-15 and CK-MB, cTnI, Mb were positively correlated ( r =0. 558, r =0. 579, r =0. 545, P 〈0.01). Coriclusion In the pathogenesis of AMI, blood GDF-15, CK-MB, cTnl, Mb, and STEMI were in- creased obviously. GDF-15 and CK-MB, eTnI, Mb were positively correlated, the combined detection of these indexes is helpful for early diagnosis and risk stratification of AMI.
出处 《疑难病杂志》 CAS 2014年第8期790-792,共3页 Chinese Journal of Difficult and Complicated Cases
关键词 心肌梗死 急性 生长分化因子-15 肌酸激酶同工酶 肌钙蛋白I 肌红蛋白 相关分析 Myocardial infarction, acute Growth differentiation factor-15 Creatine kinase isoenzyme Troponin I Myoglobin Correlation analysis
  • 相关文献

参考文献12

  • 1Brown DA, Breit SN, Buring J, et al. Concentration in plasma of macro- phage inhibitory cytokine-1 and risk of cardiovascular events in women : a nested case-control study[ J ]. Tan M, Wang Y, Guan K, et al Lancet ,2002,359 ( 9324 ) :2159-2163.
  • 2PTGF-beta, a type beta transforminggrowth factor (TGF-bcta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway [ J ]. Proc Natl Acad Sci USA ,2000,97 ( 1 ) : 109-114.
  • 3Kempf T, Eden M, Strelau J, et al. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury [ J ]. Cire Res, 2006,98 ( 3 ) : 351- 360.
  • 4Anand I S, Kempf T, Rector TS, et al. Serial measurement of growth-dif- ferentiation factor-15 in heart failure: relation to disease severity and prognosis in the Valsartan Heart Failure Trial[ J]. Circulation,2010, 122 (14) : 1387-1395.
  • 5Johnen H, Kuffner T, Brown DA, et al. Increased expression of the TGF- b superfamily cytokine MIC-1/GDF15 protects ApoE (-/-) mice from the development of atherosclerosis [ J ]. Cardiovasc Pathol, 2012,21 (6) :499-505.
  • 6Bonaca MP, Morrow DA, Braunwald E, et al. Growth differentiation fac- tor-15 and risk of recurrent events in patients stabilized after acute coro- nary syndrome: observations from PROVE IT-TIMI 22[J]. ArteriosclerThromb Vasc Biol,2011,31 ( 1 ) :203-210.
  • 7孙国强,李玉波.血清GDF-15表达水平与冠心病的相关研究[J].现代预防医学,2012,39(20):5380-5381. 被引量:6
  • 8Kempf T,Bj~rklund E, Olofsson S, et al. Growth-differentiation factor- 15 improves risk stratification in ST-segment elevation myocardial infarc- tion[J]. Eur Heart J,2007,28(23) :2858-2865.
  • 9Khan S,Dhillon K,Kelly D,et al. 1 gTowth differentiation factor 15 as a prognostic marker in patients with acute myocardial infarction[ J]. Eur- Heart, 2009,30 ( 9 ) : 1057-1065.
  • 10白莲莲.肌红蛋白和肌钙蛋白I联合检测在急性心肌梗死中的临床意义[J].中国卫生产业,2013,10(2):127-128. 被引量:2

二级参考文献22

共引文献9

同被引文献78

  • 1杨永健,张鑫,孙梅芹.血管紧张素Ⅱ受体拮抗剂对心肌重构的保护机制[J].临床心血管病杂志,2005,21(11):663-665. 被引量:2
  • 2张利群,贾志梅,王洪涛,汪薇.缬沙坦对大鼠心肌梗死后心室重构的影响[J].中国医科大学学报,2007,36(1):57-58. 被引量:3
  • 3REYNER K, HEFFNER A C, GARVEY J L, et al. Successful use of intra - arrest thrombolysis for electrical storm due to acute myo- cardial infarction[ J]. Am J Emerg Med, 2015, 33(7) : 990 -995.
  • 4OLSON R E, VOJVODIC R W, BEITENCOURT J, et al. Re- cruiting for Acute Myocardial Infarction Cell Therapy Trials: Chal- lenges and Best Practices for the CCTRN [ J]. Clin Res (Alex) , 2014, 28(4) : 71 -77.
  • 5Steg PG,James SK,Atar D,et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation[J]. Eur Heart J,2012,01(03):215-7.
  • 6Thiele H,Zeymer U,Neumann FJ,et al. Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): final 12 month results of a randomised, open-label trial[J]. The Lancet,2013,382(9905):1638-45.
  • 7Dharmarajan K,Hsieh A F,Lin Z,et al. Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia[J]. JAMA,2013,309(4):355-63.
  • 8Sabate M,Cequier A,Ifiiguez A,et aL Everolimus-eluting stent versus bare-metal stent in ST-segment elevation myocardial infarction (EXAMINATION): 1 year results of a randomised controlled trial[J]. The Lancet,2012,380(9852): 1482-90.
  • 9Houtgraaf JH,Wijnand K,Van Dalen BM,et al. First experience in humans using adipose tissue-derived regenerative cells in the treatment of patients with ST-segment elevation myocardial infarction[J]. J Am College Cardiol,2012,59(5):539-40.
  • 10BRAUNWALD E, ANTMAN E M, BEASLEY J W, et al. ACC/ AHA 2002 guideline update for the management of patients with unstable angina and non - ST-segment elevation myocardial infarction summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on the Management of Patients With Unstable Angina) [J]. J Am Coil Cardiol, 2002, 40 (7) : 1366 -1374.

引证文献8

二级引证文献105

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部