摘要
目的研究急性心肌梗死(AMI)患者血浆生长分化因子-15(GDF-15)、心肌梗死三项[肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、肌红蛋白(Mb)]表达水平及其之间的关系。方法以116例AMI患者作为AMI组,分为2个亚组,其中ST段抬高型心肌梗死(STEMI亚组)58例,非ST段抬高型心肌梗死(NSTEMI亚组)58例,采用酶联免疫吸附试验(ELISA法)测定血GDF-15水平,采用荧光免疫定量法测定CK-MB、cTnI、Mb水平;并以106例健康查体者作为健康对照组进行比较。结果AMI组血GDF-15、CK-MB、cTnI、Mb水平较健康对照组均显著增高(P<0.01),其中STEMI亚组较NSTEMI亚组升高更明显(P<0.05)。相关分析显示GDF-15与CK-MB、cTnI、Mb均呈正相关(r=0.558、r=0.579、r=0.545,P<0.01)。结论在AMI发病过程中,血GDF-15、CK-MB、cTnI、Mb水平升高,且STEMI患者升高更明显。GDF-15与CK-MB、cTnI、Mb呈正相关,联合检测可能更有助于AMI的早期诊断和危险分层。
Objective To investigate the relationship between acute myocardial infarction (AMI) patients serum growth differentiation factor-15 ( GDF-15 ), the myocardial infarction three [ isoenzyme of creatine kinase ( CK-MB), troponin I (cTnI), myoglobin (Mb) ] expression. Methods 116 cases of AMI patients as AMI group, they were divided into 2 sub- groups, the ST segment elevation myocardial infarction (STEMI group) with 58 eases, non ST segment elevation myocardial infarction (NSTEMI) group with 58 cases, using enzyme-linked immunosorbent assay (ELISA method) to determine the ser- um GDF-15 level, CK-MB, cTnI, Mb levels were determined using fluorescence immunoassay method; and 106 healthy sub- jects as healthy controls were compared. Results AMI group'sGDF-15, CK-MB, cTnI, Mb levels were increased than health- y control group significantly ( P 〈 0.01 ), where STEMI sub group were increased obviously than in NSTEMI group ( P 〈 0. 05). Correlation analysis showed that GDF-15 and CK-MB, cTnI, Mb were positively correlated ( r =0. 558, r =0. 579, r =0. 545, P 〈0.01). Coriclusion In the pathogenesis of AMI, blood GDF-15, CK-MB, cTnl, Mb, and STEMI were in- creased obviously. GDF-15 and CK-MB, eTnI, Mb were positively correlated, the combined detection of these indexes is helpful for early diagnosis and risk stratification of AMI.
出处
《疑难病杂志》
CAS
2014年第8期790-792,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
心肌梗死
急性
生长分化因子-15
肌酸激酶同工酶
肌钙蛋白I
肌红蛋白
相关分析
Myocardial infarction, acute
Growth differentiation factor-15
Creatine kinase isoenzyme
Troponin I
Myoglobin
Correlation analysis