血浆同型半胱氨酸检测对2型糖尿病的预警价值

Value of the Detection of Plasma Homocysteine in Early Warning of Type 2 Diabetes Mellitus

【目的】探讨血浆同型半胱氨酸（Hcy）含量与2型糖尿病（T2DM）发生发展的关系。【方法】分别检测42例T2DM患者（T2DM组）、64例空腹血糖受损患者（空腹血糖受损组）的Hcy、空腹血糖（FPG ）、糖化血红蛋白（HbA1c）及尿微量白蛋白（UMALB），并与86名健康体检者（对照组）进行比较，同时比较分析 Hcy 与 FPG、HbA1c、UMALB的相关性。【结果】 T2DM组血浆中Hcy、HbA1c、FPG及UMALB水平均显著高于对照组（ P＜0．05），空腹血糖受损组FPG、Hcy及UMALB的平均值显著高于对照组（ P＜0．05），HbA1c略升高，但差异无统计学意义（ P ＞0．05）。Pearson相关分析显示血浆 Hcy的升高与FPG（ r ＝0．465）、HbA1c（ r ＝0．246）、UM-ALB（ r ＝0．775）呈正相关（均 P ＜0．05）。【结论】Hcy水平与T2DM的发生和发展密切相关，空腹血糖受损者检测Hcy对于预防T2DM有重要意义。

Objective To explore the correlation of plasma homocysteine （Hcy） level with the occurrence and development of type 2 diabetes mellitus（T2DM） .[Methods] Plasma Hcy ,fasting glucose（FPG） ,glycosylated hemoglobin （HbA1c） and urine microalbumin（UMALB） in 42 T2DM patients（T2DM group） and 64 patients with impaired fasting glucose（IFG）（IFG group） were measured and compared with those in 86 healthy subjects（control group） .The correlation of Hcy with FPG ,HbA1c and UMALB was analyzed .[Results] Plasma levels of Hcy ,HbA1c ,FPG and UMALB in T2DM group were higher than those in control group significantly （ P 〈0 .05） .The average values of FPG ,Hcy and UMALB in IFG group were higher than those in control group significantly （ P〈0 .05） .HbA1C was increased slightly , but there was no significant difference （ P〉0 .05） .Pearson correlation analysis showed that Hcy was positively correlated with FPG（ r =0 .465 ,P〈0 .05） ,HbA1c（ r =0 .246 ,P〈0 .05） and UMALB（ r =0 .775 ,P〈0 .05） .[Conclusion]Plasma Hcy level is closely related with the occurrence and development of T 2DM .The detection of Hcy in patients with IFG is of important significance for preventing T 2DM .