硝苯地平对脑出血患者脑损伤保护作用的临床观察

Clinical Research of the Protective Effect of Nifedipine on Brain Injury in Patients with Cere-bral Hemorrhage

【目的】探讨硝苯地平对脑出血患者脑损伤的保护作用。【方法】将58例脑出血患者随机分为常规治疗组（对照组）与硝苯地平治疗组（观察组），患者均分别在治疗前后观察临床神经功能缺损评分（MESS）、Barthel指数评分（BI）、血肿体积、水肿带体积。【结果】针对治疗的总有效率，观察组总有效率为75％，显著高于对照组（60％）。此外，与对照组比较，硝苯地平治疗后明显提高了临床神经功能缺损评分减少值、BI评分增加值以及显著降低了治疗后日常生活活动的依赖程度。观察组和对照组经治疗后血肿体积均明显缩小，但血肿体积减小值两组比较无显著性差异。两组治疗后水肿带均明显缩小，但观察组明显增加了水肿带体积减少值（ P ＜0．05）。【结论】硝苯地平治疗明显可以减轻脑出血患者的脑水肿，保护神经细胞，减轻患者神经功能缺损程度，提高患者生活质量。

Objective To explore the protective effect of nifedipine on brain injury in patients with cerebral hemorrhage .[Methods] A total of 58 patients with cerebral hemorrhage were randomly divided into routine treatment group and nifedipine treatment group .Clinical neurologic impairment score ,Barthel index （BI） score ,hematoma volume and edema area volume of patients before and after treatment were observed .[Results] Total effective rate of nifedipine group was 75% ,which was markedly higher than that of routine treatment group（60% ） .Compared with routine treatment group ,the decline value of clinical neurological impairment score and BI score were elevated and the dependency level of daily living activity was markedly reduced in nifedipine group after treatment .Hematoma volume in two groups after treatment was obviously decreased , but there was no significant difference in the decline value of hematoma volume between two groups after treatment .Edema area of two groups after treatment was also decreased ,but the decline value of edema area volume in nifedipine group was obviously elevated .[Conclusion] Nifedipine can obviously alleviate brain edema , protect nerve cells ,decrease neurologic impairment level and improve quality of life of patients with cerebral hemorrhage .