AEG-1在大肠癌中的表达和意义

Expression and Significance of AEG-1 in Large Intestinal Cancer

【目的】探讨A EG-1在大肠癌组织中的表达及意义。【方法】选取本院2008年大肠癌患者40例（观察组），良性肠黏膜组织病例40例（对照组），采用免疫组化法检测大两组组织中A EG-1的表达，并分析其与临床病理指标的相关性。【结果】观察组A EG-1在大肠癌组织中表达显著高于对照组（ P ＜0．05）；A EG-1在大肠癌组织中的表达与性别、年龄、病理分化程度、癌胚抗原（ CEA）等无关，与 TNM 分期、淋巴结转移相关。【结论】A EG-1过度表达与大肠癌发生、发展、转移可能具有相关性。

Objective To explore the expression and significance of AEG-1 in large intestinal cancer .[Methods] A total of 40 patients with large intestinal cancer （observation group） and 40 patients with benign intestinal mucosa（control group） of our hospital in 2008 were selected .Immunohistochemical method was used to detect the expression of AEG-1 .The correlation between AEG-1 and clinicopathological indicators was analyzed .[Results]The expression level of AEG-1 in large intestinal cancer tissue of observation group was significantly higher than that in control group（ P 〈0 .05） .The expression of AEG-1 in large intestinal cancer had no correlation with gender ,age ,pathological differentiation degree and carcinoembryonic antigen （CEA ） in colorectal carcinoma ,but was related to TNM stage and lymph node metastasis .[Conclusion] The overexpression of AEG-1 may be related to the occurrence ,development and metastasis of large intestinal cancer .