无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的疗效研究

Research on the effect of NIPPV on patients with chronic obstructive pulmonary disease combine with respiratory failure

目的:分析无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床效果。方法:选取176例接受治疗的慢性阻塞性肺疾病合并呼吸衰竭患者,随机分为对照组(接受常规治疗)和观察组(接受无创正压通气治疗),比较两组患者治疗后呼吸及血气相关指标、炎症因子水平、插管率及病死率等差异。结果:观察组患者接受无创正压通气(NIPPV)治疗后的PH值、动脉血氧分压(PaO2)及SaO2明显高于对照组患者,二氧化碳分压(PaCO2)、心率(RR)及呼吸频率(HR)值明显低于对照组患者;观察组患者接受NIPPV治疗后的炎症因子水平明显低于对照组患者;观察组患者接受NIPPV治疗后的插管率及病死率均明显低于对照组患者。结论:NIPPV可以有效优化慢性阻塞性肺疾病合并呼吸衰竭患者的血气及呼吸指标,降低炎症因子水平,减少插管及病死事件的发生,具有积极的临床意义。

Objective：To analyze the effect of NIPPV on patients with chronic obstructive pulmonary disease combine with respiratory failure.Methods：Chosen patients in our hospital as research subjects,randomly assigned to control group receiving conventional treatment and observation group receiving NIPPV treatment,compared with respiration and blood-related indicators,inflammatory factors levels,intubation and mortality rate.Results：Observation group patients after NIPPV treatment PH,PaO2,SaO2 value were significantly higher than control group patients,PaCO2,RR,HR value were significantly lower than control group patients; Observation group patients inflammatory cytokine levels after treatment was significantly lower than control group patients; Observation group patients＇ intubation and mortality rates after treatment were significantly lower than control group patients.Conclusion：Noninvasive positive pressure ventilation can effectively optimize blood and respiratory index in chronic obstructive pulmonary disease patients with respiratory failure,lower levels of inflammatory factors,reduce the incidence of intubation and death,with a positive clinical significance.