复方谷氨酰胺海藻植物胶囊释放度的测定

Determination of the Drug Release of Compound Glutamine Seaweed Plant Capsules

选择复方谷氨酰胺作为模型药物,填充于海藻植物胶囊壳中,测定其在体外释放度。结果表明,在模拟胃环境中复方谷氨酰胺2 h无药物释放;在模拟肠环境中35 min时,复方谷氨酰胺累计释放度已达标示量的70%;在60 min时,累计释放度达92%,符合药典规定。

The compound glutamine is chosen as a model drug and packed into the seaweed plant capsule shells. The in vitro drug release of capsules is determined. The results show that the drug release of compound glutamine seaweed plant capsule is0 after 2 hours in a simulated gastric environment and the drug release has reached 70% at 35 min and 92% at 60 min in simulated intestinal environment,can meet the pharmacopoeia standards.