中医药治疗类风湿性关节炎随机对照试验的Meta分析

Mata-analysis in Randomized Controlled Trials of Treating Rheumatiod Arthritis With Traditional Chinese Medicine

目的系统评价中医药治疗RA的临床疗效。方法通过检索相关文献,对符合标准的试验进行质量评价和Meta分析。结果有17篇文献符合标准,纳入人数共计1672例。经Meta分析显示,中医药在提高RA的临床疗效,改善关节肿胀、关节疼痛或压痛、晨僵、ESR、CRP等方面均优于单纯西药治疗。结论中医药在治疗RA方面与单纯西药相比更有优势,但由于纳入的临床试验方法学质量较低,以及本研究自身的不足,故现有证据强度不够,尚需开展高质量、能被广泛认同的临床试验予以证实。

Objective To evaluate the clinical efficacy of Traditional Chinese medicine in treating Rheumatiod Arthritis in terms of the evidence-based medicine skill. Methods Electronic and manual searches were conducted to identify RCTs. Methodological quality and Meta-analysis of the included trails were performed in terms of Jadad scales and allocation concealment. Results There were 17 RCTs and1672 patients met the inclusion criteria. The results of meta-analysis showed that the indexes of evaluation for treatment group were better than control group. Conclusion Traditional Chinese medicine may have advantages in clinical efficacy,but the poor methodological quality of included studies seriously weakened the validity of the meta-analysis which were needed to further assess by the high quality and large sample sized RCTs.