胚胎移植困难对体外受精-胚胎移植妊娠结局的影响

The impact of difficult embryo transfer on the outcome of in vitro fertilization-embryo transfer

目的探讨胚胎移植过程的难易程度对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法分析该院妇产科生殖中心2011年1月至2012年12月209个移植困难新鲜周期(困难移植组),与同期进行胚胎移植顺利的2 489个新鲜周期(容易移植组),比较胚胎困难移植组与胚胎容易移植组的助孕情况和临床结局。结果困难移植组与容易移植组比较,移植管血染率(51.20%vs 27.68%,P<0.05)、胚胎种植率(31.14%vs 35.54%,P<0.05)和临床妊娠率(46.41%vs 55.56%,P<0.05)比较差异有统计学意义;但异位妊娠率及流产率比较差异无统计学意义(P>0.05)。结论胚胎移植困难会影响IVF-ET的临床妊娠结局,移植过程中应尽量避免困难移植,以提高临床妊娠率。

Objective To evaluate the effect of the difficult embryo transfer on the clinical pregnancy outcome of in vitro fertilization-embryo transfer（IVF-ET）.Methods There were 209 fresh cycles of difficultly transferring and 2 489 fresh cycles of easily embryo transferring between January 2011 and December 2012.The clinical outcome was compared.Results There were statistically significant differences in the catheter blood staining rates（51.20% vs 27.68%,P〈0.05）,implantation rate（31.14% vs 35.54%,P〈0.05）,and clinical pregnancy rate（46.41% vs 55.56%,P〈0.05）between the two groups.There was no significant difference in the rates of ectopic pregnancy and miscarriage between the two groups（P〉0.05）.Conclusion Difficulty ET will influence the clinical pregnancy.Therefore,all efforts should be made to avoid the difficult transfer in order to increase the pregnant rate.