肝细胞癌多普勒超声征象与血清HMGB1、VEGF水平的关系

The relationship between the ultrasonic sign and expression of HMGB1,VEGF in serum of hepatocellular carcinoma

目的探讨肝细胞癌多普勒超声征象与血清高迁移率族蛋白B1(HMGB1)和血管内皮生长因子(VEGF)表达的关系。方法采用多普勒超声对96例肝癌患者癌肿大小进行大体形态分型,同时检测血流分级,采用ELISA法测定患者血清HMGB1和VEGF的水平。结果结节型和巨块型患者血清HMGB1明显高于小肝癌型(53.5±4.3)ng/mL,巨块型患者血清HMGB1(102.9±9.7)ng/mL明显高于结节型(76.0±6.2)ng/mL(P<0.05);小肝癌型、结节型、巨块型患者血清VEGF比较差异无统计学意义(P>0.05)。随血流分级增高,血清HMGB1和VEGF水平亦逐渐增加(P<0.05)。结论血清HMGB1与肝细胞癌形态分型有关,血清HMGB1和VEGF水平随超声血流分级增加而升高。

Objective To investigate the relationship between the ultrasonic sign and expression of HMGB1,VEGF in serum of hepatocellular carcinoma patients.Methods Doppler ultrasound was used to inspect the size of the tumor and to analyze the typing and flow classification.The ELISA was used to check the HMGB1 and VEGF in serum.Results The expression level of HMGB1 in nodular and massive group was higher than that in small modelgroup（53.5±4.3）ng/mL.The expression level of HMGB1 in massive group（102.9±9.7）ng/mL was higher than that in nodular group（76.0±6.2）ng/mL（P〈0.05）.The VEGF among three groups had no difference（P〈0.05）.With the increase of flow classification,the levels of HMGB1 and VEGF also increased（P〈0.05）.Conclusion The HMGB1 in serum has some connection with morphology types.The HMGB1 and VEGF in serum increase with the flow classification.