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高分辨质谱在药物代谢产物鉴定中的应用进展 被引量:4

Recent Advances in Metabolite Identification by High Resolution Mass Spectrometry
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摘要 高分辨质谱由于具有快速、灵敏、专属的特点,在药物及代谢产物的鉴定中有着重要的应用。文章综述了质谱系统在代谢物鉴定中的进展,重点介绍了多种新型高分辨质谱数据采集和处理技术在代谢物鉴定方面呈现的优势,以期为代谢产物鉴定研究提供参考。 The high resolution mass spectrometry (HR -MS)plays a key role in detection and identification of drugs and metabolites owing to the rapid, sensitive and specific characteristics. This review outlines the advancement of mass spectrometry system in metabolite identification, and emphasizes on the superiorities of multiple new types of data acquisition and data mining techniques for metabolite identification, so as to provide references for further study of metabolism.
出处 《辽宁中医杂志》 CAS 2014年第8期1764-1768,共5页 Liaoning Journal of Traditional Chinese Medicine
基金 国家自然基金项目(81001633) 国家重大新药创制项目(2012ZX09101202) 国家973计划项目(2012CB723504)
关键词 代谢物鉴定 高分辨质谱 数据挖掘和处理技术 metabolite identification high resolution mass spectrometry ( HR - MS) data mining techniques
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