Neuritin在胃癌中的表达水平及意义

Expression of Neuritin and its clinical significance in gastric cancer

目的：了解Neuritin在胃癌中的表达情况，探讨Neuritin表达与胃癌发生、发展的相关性。方法收集2010～2013年在石河子大学第一附属医院切除胃癌组织标本的患者58例，利用免疫组织化学法检测胃癌、癌旁正常胃组织中Neuritin的表达水平的差异。结果免疫组织化学法结果显示Neuritin在胃癌组织中阳性率为96．55％（56/58），在癌旁正常组织中阳性率为94．83％（55/58），两组比较差异无统计学意义（P＞0．05）；Neuritin在胃癌组织中强阳性率为82．76％（48/58），在癌旁正常组织中强阳性率为15．52％（9/58），两组比较差异有统计学意义（P＜0．05）。Neuritin的表达与患者性别、年龄、TNM 分期、浸润深度、淋巴结转移、分化程度、病理学类型及远处转移无相关性（均 P＞0．05）。结论 Neuritin在胃癌组织与癌旁正常组织中的表达水平存在差异，Neuritin在胃癌组织中存在高表达。

Objective To research the expression of Neuritin in gastric cancer .and the relationship between the expression of Neuritin with the occurrence and development of gastric cancer .Methods Collected 58 surgical specimens of gastric cancer from 2010 to 2013 in the first affiliated hospital of Shihezi University ,immunohistochemistry was used to examine the expression of Neu-ritin in gastric cancer and normal tissues near the cancer of the stomach .Results Immunohistochemical staining showed that Neu-ritin was moderately or highly expressed in 96 .55% （56/58） of gastric cancer ,and Neuritin was moderately or highly expressed in 94 .83% （55/58） of normal tissues near the cancer .There was no statistically significantly difference between two groups （P〉0 .05）;Neuritin was highly expressed in 82 .76% （48/58） of gastric cancer ,and Neuritin was highly expressed in 15 .52% （9/58） of normal tissues near the cancer ,differences between the two groups had statistically significantly （P〈0 .05） .Expression of Neuritin was not correlated with gender ,age ,TNM stage ,infiltration depth ,lymph node metastasis ,differentiated degree ,the pathologic type or distant metastasis（P〉 0 .05） .Conclusion The Neuritin expression level between gastric cancer and normal tissues near the cancer exist differences .There is overexpression of neuritin in gastric cancer .