TGF-β_1/smads信号转导通路在IPF病程中的作用初探

Role of TGF β_1/Smads Signal Transduction Pathway in Course of IPF

特发性肺间质纤维化为一种严重的呼吸系统疾病,其特点主要为慢性、弥漫性、进行性以及限制性通气功能障碍,该病病因复杂且预后较差,目前尚缺乏安全有效的治疗方案。近年来,细胞因子网络在IPF发生、进展过程中的作用越发受到重视,其中TGF-β1为目前研究最多、公认的重要因素。该文简单叙述IPF的分子机制、TGF-β1/smads信号转导通路的作用途径,并对其致IPF的病理作用给出较为详尽的解答。

Idiopathic pulmonary fibrosis a serious respiratory disease. Its characteristics is chronic, diffuse, progressive and lung restrictive ventilatory dysfunction. The cause of it is complexed and prognosis is poor. So far, we have no safe and effective treatment to treat it. Recently, during the progress of IPF, the functions of cytokine network is more and more realized. As one of them, TGF- β1 is the most studied and accepted factor. The artical briefly describes the molecular mechanism of IPF and the function pathway of TGF- β1/smads. At the same time, we expound the pathological role of it detailedly.