先兆流产中绒毛膜促性腺激素与游离β亚单位及黄体酮的表达及意义分析

Expression and significance analysis of human chorionic gonadotropin, free beta subunit and progesterone in the treatment of early threatened abortion

目的探讨先兆流产患者绒毛膜促性腺激素(β-HCG)与游离β亚单位(fβ-HCG)及黄体酮含量(Progesterone,P)的表达及意义。方法先兆流产患者50例,设为观察组,正常早孕妇女50例为对照组,采用化学发光分析法对两组研究对象血样进行β-HCG、fβ-HCG、P含量的检测,每隔48 h对研究对象进行同样条件下的β-HCG、fβ-HCG、P含量的检测。48 h倍增率=(48 h测定值-初测值)÷初测值。结果β-HCG、P含量组间比较差异无统计学意义(P>0.05),fβ-HCG含量观察组显著高于对照组,差异有统计学意义(P<0.05)。β-HCG、fβ-HCG 48 h倍增率比较,差异无统计学意义(P>0.05)。结论检测并综合分析β-HCG、fβ-HCG及黄体酮在先兆流产中的表达,对判断妊娠结局具有参考价值。

Objective To study expression and significance of beta human chorionic gonadotropin（β-HCG）, free beta subunit （fβ-HCG） and progesterone in the treatment of early threatened abortion. Methods Selected 50 patients with threatened abortion as observation group. Selected 50 normal pregnancy women as control group, β-HCG, fβ-HCG and progesterone content in blood sample were detected with method of chemiluminescence, every 48 h for a detection under the same condition. 48 h multiplication rate=（48 h measurements minus initial measured value） divide initial measured value. Results β-HCG, progesterone content in two groups have no statistical significance（P〉0.05）, fβ-HCG in observation group was significantly higher than that of control group, the difference was statistically significant（P〈0.05）.β-HCG 48 h, fβ-HCG multiplication rate were no statistically significant difference（P〉0.05）. Conclusion Testing and comprehensive analysis ofβ-HCG, fβ-HCG and progesterone in threatened abortion have reference value to determine the pregnancy outcome.