摘要
目的观察阿法迪三对慢性肾功能衰竭血透患者继发甲状旁腺功能亢进及贫血的治疗效果。方法将2012-01~2013-09在本院行血液透析的慢性肾功能衰竭继发甲状旁腺功能亢进患者80例随机分为2组,予以治疗基础疾病、血液透析、口服补充钙剂,观察组加服阿法迪三0.25~0.5μg/d治疗,疗程为3个月。比较治疗前后2组患者的肾功能指标、血红蛋白、血清铁蛋白、转铁蛋白饱和度、血清钙、磷、甲状旁腺素等指标的变化。结果治疗3个月后,2组患者肾功能、尿蛋白、贫血指标均较治疗前明显改善（P〈0.05）。观察组尿素氮、蛋白尿、贫血改善,血钙升高,血全段甲状旁腺素（iPTH）水平逐步下降,促红细胞生成素（EPO）的用量下降,优于对照组（P〈0.05）。2组患者血磷、铁的储存和利用（SF、TSAT）的指标差异无统计学意义（P〉0.05）。结论肾功能衰竭行血液透析继发甲状旁腺功能亢进的患者应用阿法迪三治疗,可明显升高血钙,降低甲状旁腺素,改善肾功能和贫血,减少EPO的用量。
Objective To investigate the clinical effect of alpha-D3 in the treatment of patient with chronic renal failure in maintenance hemodialysis and secondary hyperparathyroidism. Methods A total of 80 patients with chronic renal failure and secondary hyperparathyroidism in the hospital from Jan 2012 to Sep 2013 were randomly divided into 2 groups.The underlying disease of all patients were treated, all patients were treated by hemodialysis, oral calcium, while patietats in the observation group were also treated by oral alpha-D3 treatment （0.25-0.5 μg/d）.Then the level of renal function, hemoglobin, serum ferritin, degree of saturation of transferring, serum calcium, phosphorus and parathyroid hormone were detected and compared before and after the treatment. Results The level of renal function, urine protein, and hemoglobin after treated was significantly better than that of before treatment （P 〈 0.05 improvement degree of renal function, hemoglobin, serum calcium, parathyroid hormone an In observation group, the the dosage of EPO was significantly better than that of control group （ P 〈 0.05 ）. The level of serum phosphorus, serum ferritin and degree of saturation of transferring did not change significantly （P〉0.05）.Conclusion In patient with chronic renal failure in maintenance hemodialysis and secondary hyperparathyroidism, alpha-D3 can increase the serum calcium level, degrade the serum parathyroid hormone level and the dosage of EPO,improve the renal function and hemophthisis.
出处
《今日药学》
CAS
2014年第7期527-530,共4页
Pharmacy Today
