C-反应蛋白与慢性阻塞性肺疾病急性加重严重程度关系的研究

Correlation between C-reactive protein and the severity of AECOPD

目的:探讨血清C-反应蛋白(CRP)水平与慢性阻塞性肺疾病急性加重(AECOPD)严重程度的关系及临床意义。方法:选取急诊入院病例98例(52例普通病房患者,46例ICU患者),门诊健康体检者52例。分别检测各组的CRP水平及血沉(ESR),利用相关分析研究CRP与AECOPD严重程度的关系。结果:AECOPD普通病房患者及ICU病房患者血浆CRP及ESR水平均高于体检健康者(P<0.001),ICU组CRP水平高于普通病房组(P<0.001),普通病房组、ICU组ESR差异无统计学意义(P<0.05);AECOPD患者(包括普通病房组、ICU组)的CRP与ESR有显著相关性(r=0.776,P=0.001),健康体检者正常组CRP与ESR无相关关系(r=0.063,P=0.659)。结论:CRP水平可作为AECOPD严重程度的预测指标之一,其检测可对不同程度的AECOPD患者进行评估,对指导AECOPD治疗、评价预后均具有重要临床价值。

Objective To investigate correlation between serum C-reactive protein（ CRp）levels and the severity of AECOpD and its clinical significance. Method A total of 98 inpatients with AECOpD were analyzed as AECOpD group（52 in the regular ward and 46 in the ICU ward）,while 52 patients without COpD were enrolled as control group. CRp and EsR were measured in both groups. Results CRp and EsR levels of patients in the regular ward and ICU ward were increased compared with that in the control group（ P〈0. 001）,CRp level in the ICU ward group was increased compared with that in the regular ward group（ P〈0. 001 ）,there was no significant changes of EsR in both groups. There was a significant correlation between CRp and EsR（r=0. 776,P=0. 001）,in patients with AECOpD（including regu-lar ward group and ICU ward group）CRp of the control group had no correlation with EsR（r=0. 063,P=0. 659）. Conclusion The ser-um of CRp may be regared as one of the predictors of the severity of AECOpD. By detection of CRp,it help to evaluate the severity,and fur-ther guide the treatment and prognosis evaluation in AECOpD patients.