糖胰敏对2型糖尿病糖脂代谢紊乱的改善作用及机制研究

Improving effect of Tangyimin on glucose and lipid metabolism disorder in type 2 diabetes mellitus and its mechanism

目的探讨糖胰敏对2型糖尿病(T2DM)模型大鼠糖脂代谢紊乱的改善作用及相关机制。方法采用高糖高脂饲料喂养联合低剂量链脲佐菌素(STZ)腹腔注射建立2型糖尿病大鼠模型。将90只Wistar大鼠分为正常对照组、模型对照组、达美康组及糖胰敏高、中、低剂量组。治疗前后动态监测各组大鼠空腹血糖(FBG),血脂包括三酰甘油(TC)、总胆固醇(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、空腹血清胰岛素(FINS)。计算胰岛素抵抗指数(IRI)、胰岛素敏感指数(ISI)、胰岛素分泌指数(IS)。结果与正常对照组比较,模型对照组大鼠FBG、FINS、TG、TC、LDL、IRI水平均明显升高(P均<0.05),ISI、IS、HDL水平均明显降低(P均<0.05)。糖胰敏治疗2周后大鼠血糖开始下降,治疗4周后,糖胰敏中、高剂量组以及达美康组大鼠FBG、TC、TG、LDL-C、IRI水平均明显降低(P均<0.05),而HDL-C、ISI和IS水平均明显升高(P均<0.05)。结论糖胰敏可通过调节糖脂代谢,降低脂毒性,增强胰岛组织对胰岛素的敏感性,从而有效发挥其改善糖脂代谢紊乱和降脂降糖的作用。

Objective It is to explore the improving effect of Tangyimin on glucose and lipid metabolism disorder in type 2 diabetes mellitus （T2DM） rats and to explore its correlated mechanism .Methods The rat models of T2DM were established by feeding with high glucose and lipid fodder combined with STZ by intraperitoneal injection .90 Wistar rats were divided into normal control group , model group, Dameikang group and high , moderate and low dose of Tangminkang groups .The levels of FBG, TC, TG, HDL-C, LDL-C, FINS were determined before and after the treatment .IRI, ISI and IS were calculated and compared.Results Compared with those in normal control group , the levels of FBG, FINS, TG, TC, LDL and IRI were significantly higher（P〈0.05）, while the levels of ISI, IS and HDL were obviously lower （P〈0.05） in model group.After two weeks＆#39;treatment with Tangyimin , the level of FBG began to decrease , in four weeks after treatment , the levels of TC , TG, LDL-C and IRI decreased obviously , while the levels of HDL-C, ISI and IS increased in moderate and high dose of Tangy-imin groups and Dameikang group （P〈0.05）.Conclusion Tangyimin can effectively improve glucose and lipid metabolism disorder and decrease and play hypoglycemic effect and hypolipidemic effect by regulating glucose and lipid metabolism , relie-ving fatty toxicity and enhancing sensitivity of insulin in pancreatic islets .