LifePort保存心脏死亡器官捐献供肾的临床研究

Clinical research of transporting kidney from donation after cardiac death by LifePort

目的：探讨采用LifePort保存心脏死亡器官捐献（DCD）供肾对移植肾功能恢复的影响。方法：分析解放军三〇三医院2012年8月~2013年10月期间30个DCD案例肾移植后受者的临床资料。根据同一供体两只供肾采用不同的保存方式,随机分入LifePort组（n=30）和普通冷藏组（n=30例）,比较两组受者肾功能恢复延迟（DGF）、急性排斥反应（AR）等并发症的发生率及移植肾功能恢复等情况。结果：LifePort组受者的DGF发生率为20%（6/30）,而普通冷藏组的DGF发生率为46.7%（14/30）,差异有统计学意义（P〈0.05）。两组间AR发生率、围手术期移植肾存活率及受者存活率的差异无统计学意义（P〉0.05）。LifePort组受者术后出院时血清肌酐恢复优于普通冷藏组,且平均住院时间较短,差异有统计学意义（P〈0.05）。结论：LifePort能有效改善离体DCD供肾的保存质量,降低受者DGF发生率,有利于移植肾功能恢复。

Objective：To explore the effects of renal function recovery followed by kidney transplantation pumped by LifePort Kidney Transporter from donation after cardiac death（DCD）.Method：From August 2012 to October 2013,the clinical data of 30 cases of renal transplantation from DCD were retrospectively analyzed in the303 rd Hospital of PLA.Two donated kidneys from one donor were randomly divided into groups given LifePort（n=30）and not given LifePort（n=30）.The incidence of postoperative renal delayed graft function（DGF）and acute rejection（AR）between two groups were compared.Result：The incidence of DGF was 20%（6/30）in the recipients given LifePort,and 46.7%（14/30）in those not given LifePort.The statistical difference is significant（P 〈0.05）.While there is no statistical difference between two groups in AR and other complications（P 〉0.05）.The recovery of serum creatinine in recipients given LifePort was better than those not given LifePort with shorter average hospitalization time,and the statistical difference is significant（P〈0.05）.Conclusion：LifePort can effectively improve the preservation of kidney from DCD and can reduce the incidence of DGF in recipients,which will benefit to graft function recovery.