原发性膀胱恶性淋巴瘤1例报告并文献复习

Primary malignant lymphoma of the bladder:one case report and literature review

目的:探讨原发性膀胱恶性淋巴瘤(PMLB)的临床和病理特点,提高对该病的认识和诊治水平。方法:回顾性分析1例PMLB患者的临床病理资料,复习相关文献并讨论其发病特点、影像学特征、治疗及预后。结果:患者行经尿道膀胱肿瘤切检术,术后病理检查确诊为PMLB(弥漫性大B细胞型)。术后给予R-CHOP方案化疗4个疗程,患者一般情况良好,已存活6个月,目前仍在随访中。结论:PMLB是一种罕见的膀胱肿瘤,组织病理学检查是确诊该病的"金标准"。PMLB的最佳治疗方式及预后尚不明确,以化疗为主,辅以放疗、手术治疗的综合治疗临床应用较广泛。针对局部晚期或高恶性度的肿瘤,单纯化疗通常疗效满意。

Objective：To discuss the clinical manifestation and pathology of primary malignant lymphoma of the bladder（PMLB）and to improve the early diagnosis of PMLB.Method：Clinical and pathologic data of one patient with PMLB were retrospectively summarized and relevant literature at home and abroad was reviewed.The clinical and radiological signs were described.Result：The pathological diagnosis was PMLB（diffuse large B-cell lymphoma）.Four cycles of R-CHOP regimen were given and the patient maintained well after six months of follow-up period.Conclusion：PMLB is rare and the diagnosis is based exclusively on histological examination.The treatment of PMLB is not well defined and the prognosis remains unknown.Chemotherapy,radiotherapy and surgery either alone or in combination are considered to be therapeutic options.However,chemotherapy alone is recommended for locally advanced tumors or high grade.