趋化因子受体CCR3在乳腺癌中的表达及意义

Expression of chemokine receptor CCR3 in breast cancer and its clinicopathological significance

目的研究趋化因子受体CCR3在人乳腺癌中的表达情况,并分析其与乳腺癌相关临床病理特征的关系。方法应用免疫组织化学方法检测在150例乳腺癌及相应癌旁正常乳腺组织中CCR3的表达。分析乳腺癌中CCR3表达与患者年龄、临床分期、肿瘤大小、淋巴结转移状况、雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)、人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)等临床病理特征的相关性。结果 (1)CCR3在乳腺癌组织及癌旁正常乳腺组织中均有表达,150例乳腺癌组织中CCR3的阳性表达率为86.7%,在相应癌旁正常组织中的阳性表达率为14.0%;CCR3在乳腺癌组织的表达明显高于癌旁正常乳腺组织,差异有统计学意义(P<0.001);(2)CCR3的表达与患者的年龄、肿瘤大小、临床分期、淋巴结转移与否、ER、PR及HER-2的表达等临床病理特征无关(P>0.05)。结论 CCR3可能对乳腺癌的发展有一定的作用,CCR3在乳腺癌中表达的高低与发生淋巴结转移无明显的相关性,CCR3能否作为预测淋巴结转移的指标有待于进一步的研究。

Objective To investigate the expression of chemokine receptor CCR3 in breast cancer and its clinicopathological significance. Methods The expression of CCR3 was evaluated by immunohistochemistry in breast cancer tissues from 150 cases and the corresponding normal breast tissues. The association of CCR3 expression with clinicopathological features was analyzed. Results The positive expression rate of CCR3 in breast cancer tissues was significantly higher than that in normal breast tissues（ 86. 7% vs 14. 0%,P〈0. 001）. The expression of CCR3 was not correlated with age,cTNM stage,tumor size,axillary lymph node metastasis,estrogen receptor,progesterone receptor and HER-2 status（ P〉0. 05）. Conclusion Chemokine receptor CCR3 is highly expressed in breast cancer,however,it may be not correlated with clinicopathological features of the disease.