摘要
染色体不稳定性定义为持续获得或丢失整条染色体或染色体片段,是基因组不稳定性的主要原因。多数实体瘤具有此特征性表现。染色体不稳定性与紫杉烷类药物固有耐药,与实体瘤中的获得性多重耐药和较差预后具有相关性。目前证据显示,铂类药物比如卡铂对染色体不稳定性肿瘤特异性敏感。
出处
《实用肿瘤杂志》
CAS
2014年第4期395-398,共4页
Journal of Practical Oncology
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