腹膜透析对尿毒症患者血同型半胱氨酸的清除作用

Effects of peritoneal dialysis on clearance of homocysteine in patients with uremia

目的探讨腹膜透析对尿毒症患者血清同型半胱氨酸(Hcy)的清除作用及影响因素。方法采用酶转换法检测20例腹膜透析患者血清、24-h尿和24-h腹透液中Hcy、β2微球蛋白、尿素氮和肌酐水平,计算残余肾和腹膜透析Hcy清除率、尿素清除指数和肌酐清除率。结果 20例腹膜透析患者血清和腹膜透析液Hcy浓度分别为(13.03±13.14)μmol/L和(5.57±3.02)μmol/L,两者呈正相关(r=0.608,P<0.01)。24-h腹膜透析对Hcy的清除量亦与血清Hcy浓度呈正相关(r=0.704,P<0.01)。结论腹膜透析对Hcy有一定的清除作用。

Objective To investigate the effect of peritoneal dialysis on the clearance of homocysteine（Hey） and its influence factors in the patients with uremia. Methods Hcy contents in serum,24-hour urine and 24-hour peritoneal dialysate were detected in 20 patients with uremia. The indexes of β2-microglobulin（β2-MG）, C-reactive protein（CRP）, creatinine and urea were examined as well. Results Hcy levels in serum and peritoneal dialysate were （13. 03± 13.14）μmol/L and （5.57± 3.02）μmol/L, respectively. Hcy level in serum dialysate（r=0. 608, P〈0. 01）. The amount of was positively correlated with that in peritoneal Hcy cleared by 24-hour peritoneal dialysis was positively correlated with serum level of Hcy（r=0. 704,P〈0. 01）. Conclusions Hcy could be partly cleared by peritoneal dialysis.