血清cTnI和APACHEⅡ评分在非ACS危重患者评估中的价值被引量：1

Significance of cTnI and APACHEⅡscore in evaluation of critically ill patients without acute coronary syndrome

导出

摘要目的探讨血清肌钙蛋白I(cTnI)联合急性生理慢性健康状况评价Ⅱ(APACHEⅡ)评分在非急性冠脉综合征(ACS)危重患者评估中的价值。方法采用胶乳增强免疫比浊法检测180例非ACS危重患者血清cTnI,并行APACHEⅡ评分;以此分为cTnI A1组(cTnI≤0.50ng/ml,96例)和A2组(cTnI>0.50ng/ml,84例)或B1组(APACHEⅡ≤19分,106例)和B2组(APACHEⅡ>19分,74例)。分析病情和预后相关指标。结果 A1组APACHEⅡ评分低于A2组[(16.2±3.4)分vs.(21.6±4.5)分](P<0.05),氧合指数高于A2组(268.7±32.4vs.212.6±24.3)(P<0.05),死亡率低于A2组(21.9%vs.45.2%)(P<0.05),住院时间短于A2组[(7.4±3.6)d vs.(11.2±4.7)d](P<0.05)。联合应用血清cTnI表达和APACHEⅡ评分评估非ACS危重病患者的预后显示,cTnI正常和APACHEⅡ低分患者预期生存时间长于其他患者,死亡率低于其他患者(P<0.05或P<0.01)。结论非ACS危重病患者血清cTnI升高能反映患者疾病的严重程度,结合APACHEⅡ评分,更有利于评估非ACS危重病患者的病情和预后。 Objective To study the significance of calcitonin-I （cTnI） and acute physiology score hronic health evaluation Ⅱ （APACHE Ⅱ ） score in the evaluation of critically ill patients without acute coronary syndrome（ACS）. Methods In 180 critically ill patients without ACS,serum cTnI was detected by latex enhanced turbidimetric immunoassay and APACHE Ⅱ scoring was performed, on which the patients were assigned into groups of Al（cTnI≤0.50 ng/ml, 96 cases） and A2 （cTnI〉0. 50 ng/ml,84 cases） or B1 （APACHE Ⅱ≤ 19 points, 106 cases） and B2 （APACHEⅡ 〉 19 points, 74 cases）. The oxygenation index（OI） and mortality were analyzed. Results Compared to group A2, the paients in group A] had a lower APACHE Ⅱ score[-（21.6 ± 4.5） points vs. （16. 2 ±3.4） points] （P〈0. 05）, higher OI （212.6 ± 24. 3 vs. 268.7 ± 32.4）（P〈0. 05）, lower mortality （45.2% vs. 21.9 %）（P〈0.05） and shorter hospital stay [（ 11.2 ± 4.7） d vs. （7.4 ± 3.6） d]（P〈0.05）. An analysis by combined use of serum cTnI and APACHE Ⅱ score showed that the patients with normal serum cTnI and low APACHE Ⅱ score were with longer expected survival time and lower mortality than those with high serum cTnI and high APACHE Ⅱ score（P〈0. 05 Or P〈0. 01）. Conclusion The elevated serum cTnI can reflect the severity of critically ill patients without ACS. An analysis by combined use of serum cTnI and APACHE Ⅱ scoring is helpful in the evaluation of the illness and prognosis.

作者杨宁刘畅王宝玉

机构地区郑州大学附属郑州中心医院急诊科

出处《江苏医药》 CAS 北大核心 2014年第15期1786-1788,共3页 Jiangsu Medical Journal

关键词肌钙蛋白I 急性生理慢性健康状况评价Ⅱ 非急性冠脉综合征 Calcitonin-I Acute physiology score chronic health evaluation Ⅱ Non-acute coronary syndrome

分类号 R459 [医药卫生—治疗学]

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