胎盘生长因子与肿瘤的研究进展

Research Progress on Placental Growth Factor and Tumor

目的了解胎盘生长因子(PlGF)在肿瘤的发生、发展中的作用。方法对近年来有关PlGF的生物学作用、在肿瘤中的研究进展的相关文献进行综述。结果 PlGF是一种分泌型同源二聚体糖蛋白。PlGF具有调节滋养细胞功能的作用,诱导炎症反应,在多种肿瘤组织中呈现高表达,能够促进肿瘤生长和血管形成,针对PlGF抗体治疗取得了一定的治疗效果,但仍缺乏大宗的临床试验。结论虽然对于PlGF在肿瘤中的作用的研究结论存在着一定的争议,但是也看到了其在肿瘤治疗中的优势。相信随着研究进展,PlGF可能成为肿瘤研究、治疗的新突破点。

Objective To understand the role of placental growth factor （P1GF） in occurrence and development of tumor. Method The literatures related to biological function and research progress of P1GF in tumor in recent years were reviewed. Results PIGF was a secreted homology dimeric glycoprotein, with the regulation function on trophoblast cell, could induce inflammation reaction. It highly expressed in many tumor tissues, could promote the tumor growth and angiogenesis. The P1GF antibody treatment had a certain therapeutic effect, but it was still in clinical trials. Conclusions Although there are some disputes about conclusions on the role of P1GF in tumor, but it is obvious for the advantage in tumor treatment. With the research progress on P1GF, P1GF might be a breakthrough for tumor treatment.