Tbx3在生物起搏中的研究进展

Research Progress of Tbx3 in Cardiac Biological Pacemaker

早期生物起搏的研究大都围绕HCN通道展开,通过增强If电流来构建生物起搏器,近年来人们发现Tbx3基因在心脏传导系统尤其是窦房结的分化成熟及功能维持中发挥着重要作用,能够进一步优化生物起搏器,有可能成为生物起搏及心脏传导系统疾病新的治疗靶点。本文总结近年来Tbx3在生物起搏中的一些最新研究进展,希望为今后Tbx3的临床应用提供理论依据。

The early cardiac biological pacemaker studies were mostly around HCN channel, and how to build a biological pacemaker through the enhanced If current. In recent years, however, people found that the genes of Tbx3 could play an important role in the development of cardiac conduction system, especially in processes of the maturity of the sinoatrial node and maintenance of its function. And the Tbx3 can further optimize the biological pacemaker. Therefore, it could be a new therapeutic focus in biological pacemaker and treatment of cardiac conduction system disease. This paper summarizes some of the latest research progress of the Tbx3 in biological pacemaker in recent years. We hope that this review could provide theoretical basis for the clinical applications of Tbx3.