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老年急性髓系白血病的治疗策略分析 被引量:13

Analysis of treatment strategies for management of elderly patients with acute myeloid leukemia
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摘要 急性髓系白血病(AML)在各年龄阶段均可发病,其中约35%的新发病例年龄在75岁以上[1].强化疗使得≤60岁AML患者的5年生存率达到30%~40%乃至更高,而>60岁AML患者5年生存率不足10%,60岁是国际上认可的年轻和老年AML的年龄分界[2].有必要对老年AML患者进行危险度分层,选择个体化的治疗策略,以改善其生存和生活质量.我们回顾性分析了我院诊治的除外急性早幼粒细胞白血病(APL)的老年AML患者的临床资料及生存信息,探索其中有预后价值的因素,为患者危险度分层及治疗决策提供依据.
出处 《中华血液学杂志》 CAS CSCD 北大核心 2014年第8期763-766,共4页 Chinese Journal of Hematology
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参考文献14

  • 1Laubach J, Rao AV. Current and emerging strategies for the management of acute myeloid leukemia in the elderly [J]. Oncologist, 2008, 13 (10): 1097-1108.
  • 2Juliusson G, Anttmovic P, Derolf A, et al. Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry [J]. Blood, 2009, 113 ( 18 ) :4179 -4187.
  • 3Brunning RD, Matutes E, Harris NL, et al. Acute myeloid leuke- mia: introduction//World Health Organization Classification of Tumours: Pathology & Genetics, Turnouts of Haematopoietic and Lymphoid Tissues [M]. Lyon: International Agency for Re- search on Cancer, 2001:77-80.
  • 4Menzin J, Lang K, Earle CC, et al. The outcomes and costs of acute myeloid leukemia among the elderly[J]. Arch Intern Med, 2002, 162( 14):1597-1603.
  • 5Frohling S, Schlenk RF, Kayser S, et al. Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B [J].Blood, 2006, 108 (10):3280- 3288.
  • 6Pulsoni A, Pagano L, Latagliata R, et al. Survival of elderly patients with acute myeloid leukemia [J]. Haematologica, 2004, 89(3): 296-302.
  • 7Malfuson J, Etienne A, Turlure P, et al. Risk factors and decision criteria for intensive chemotherapy in older patients with acute myeloid leukemia [J].Haematologica, 2008, 93 (12): 1806- 1813.
  • 8Krug U, Rollig C, Koschmieder A, et al. Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based appli- cation for prediction of outcomes [J].Lancet, 2010, 376 (9757 ): 2000-2008.
  • 9Giles F J, Borthakur G, Ravandi F, et al. The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving in-duction therapy for acute myeloid leukaemia[J]. Br J Haematol, 2007, 136(4):624-627.
  • 10Savic A, Kvrgie V, Rajic N, et al. The hematopoietic cell trans- plantation comorbidity index is a predictor of early death and survival in adult acute myeloid leukemia patients [J]. Leuk Res, 2012,36(4) :479-482.

二级参考文献22

  • 1全国白血病化学治疗讨论会.急性白血病疗效标准[J].中华血液学杂志,1988,9(3):183-183.
  • 2Mrozek K, Heerema NA, Bloomfield CD. Cytogenetics in acute leukemia. Blood, 2004, 18: 115-136.
  • 3Sperr WR, Piribauer M, Wimazal F, et al. A novel effective and safe consolidation for patients over 60 years with acute myeloid leukemia: intermediate dose cytarabine (2 × 1 g/m^2 on days 1, 3, and 5 ). Clin Cancer Res,2004, 10 : 3965-3971.
  • 4Pinto A, Zagonel V, Ferraraf F. Acute myeloid leukemia in the elderly: biology and therapeutic strategies. Crit Rev Oncol Hematol, 2001, 39: 275-287.
  • 5Estey EH. General approach to, and perspectives on clinical research in, older patients with newly diagnosed acute myeloid leukemia. Semin Hematol, 2006, 43: 89-95.
  • 6Deschler B,de Witte T,Mertelsmann R,et al.Treatment decisionmaking for older patients with high-risk myelodysplastic syndrome or acute myeloid leukemia:problems and approaches. Haematologica,2006,91:1513-1522.
  • 7Kuendgen A,Germing U.Emerging treatment strategies for acute myeloid leukemia(AML) in the elderly.Cancer Treat Revi,2009,35:97-120.
  • 8Vardiman JW,Harris NL,Brunning RD.The World Health Organization (WHO) classification of the myeloid neoplasms.Blood,2002,100:2292-2302.
  • 9Charlson ME,Pompei P,Ales KL,et al.A new method of classifying prognostic comorbidity in longitudinal studies:development and validation.J Chron Dis,1987,40:373-383.
  • 10D(o)hner H,Estey EH,Amadori S,et al.Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European Leukemia Net.Blood,2010,115:453-474.

共引文献132

同被引文献81

  • 1陆米则,沈云峰,毛玉文.CAG方案治疗老年急性髓系白血病的疗效观察[J].临床血液学杂志,2007,20(3):173-174. 被引量:18
  • 2孙志东,詹林盛,王全立.关于移植后微嵌合体的研究进展[J].北京医学,2007,29(6):371-373. 被引量:2
  • 3Guo M,Hu KX,Yu CL,et al.Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients[J].Blood,2011,117:936-941.
  • 4Morris ES,MacDonald KP,Hill GR.Stem cell mobilization with G-CSF analogs:a rational approach to separate GVHD and GVL?[J].Blood,2006,107:3430-3435.
  • 5Panopoulos AD,Watowich SS.Granulocyte colonystimulating factor:molecular mechanisms of action during steady state and'emergency'hematopoiesis[J].Cytokine,2008,42:277-288.
  • 6Schmid C,Labopin M,Nagler A,et al.Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia:a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party[J].J Clin Oncol,2007,25:4938-4945.
  • 7TASSARAM, DOHNER K, BROSSART P, et al. Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients [J]. Blood, 2014, 123(26) : 4027-4036.
  • 8BAZ R, RODRIGUEZ C, FU A Z, et al. Impact of remission induction chemotherapy on survival in older adults with acute myeloid teukemia[J]. Cancer, 2007, 110(8): 1752-1759.
  • 9JULIUSSON G. Most 70- to 79-year-old patients with acute myeloid leukemia do benefit from intensive treatment[J]. Blood, 2011, 117(12): 3473-3474.
  • 10GAO S, LI Z, FU J H, et al. Decitabine in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes, Which Combined with Complex Karyotype Respectively[J]. Asian Pac J Cancer Prey, 2015, 16 (15) : 6627-6632.

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