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microRNA-21在中枢神经系统疾病中作用的研究进展 被引量：2

Recent advance in role of miR-21 in central nervous system diseases
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摘要 microRNAs（miRNAs）是长度约为19～25个核苷酸的内源性的小分子RNA,通过与mRNA结合来调节基因的转录后表达.miRNAs最早于1993年在线虫中被发现,到目前为止发现的miRNA已经有超过1000种.其中,microRNA-21（miR-21）是miRNAs中最重要的成员之一,也是研究较早、较为深入的miRNAs.研究发现miR-21在肿瘤、心血管疾病、免疫疾病、内分泌疾病和神经系统疾病的发生和发展过程中发挥重要作用.本文主要讨论目前对miR-21的表达调控机制以及在中枢神经系统肿瘤、脑血管疾病、神经退行性病变和脑创伤中作用的认识.
作者 韩召利 葛新瞳 雷平
机构地区 天津医科大学总医院神经外科 保健医疗部(老年病科)
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2014年第8期847-850,共4页 Chinese Journal of Neuromedicine
基金 国家临床重点专科建设项目：天津市科委自然基金面上项目（13JCYBJC23700）
关键词 MICRORNAS 中枢神经系统疾病 基因治疗 MicroRNAs Central nervous system disease Gene therapy
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献30

  • 1Kumarswamy R,Volkrnann I,Thum T.Regulation and function of miRNA-21 in health and disease[J].RNA Biol,2011,8 (5):706-713.
  • 2Pan X,Wang ZX,Wang R.MicroRNA-21:A novel therapeutic target in human cancer[J].Cancer Biology & Therapy,2010,10(12):1224-1232.
  • 3Volinia S,Calin GA,Liu CG,et al.A microRNA expression signature of human solid tumors defines cancer gene targets[J].Proc Natl Acad Sci U S A,2006,103(7):2257-2261.
  • 4Cai X,Hagedorn CH,Cullen BR.Human microRNAs are processed from capped,polyadenylated transcripts that can also function as mRNAs[J].RNA,2004,10(12):1957-1966.
  • 5Gaur AB,Holbeck SL,Colburn NH,et al.Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo[J].Neuro Oncol,2011,13(6):580-590.
  • 6Wang YY,Sun G,Luo H,et al.MiR-21 modulates hTERT through a STAT3-dependent manner on glioblastoma cell growth[J].CNS Neurosci Ther,2012,18(9):722-728.
  • 7Papagiarnakopoulos T,Shapiro A,Kosik KS.MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells[J].Cancer Res,2008,68(19):8164-8172.
  • 8Corsten MF,Miranda R,Kasmieh R,et al.MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas[J].Cancer Res,2007,67(19):8994-9000.
  • 9Zhang KL,Han L,Chen LY,et al.Blockage ofa miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas[J].Cancer Lett,2014,342(1):139-49.
  • 10Grunder E,D'Ambrosio R,Fiaschetti G,et al.MicroRNA-21 suppression impedes medulloblastoma cell migration[J].Eur J Cancer,2011,47(16):2479-2490.

二级参考文献9

  • 1雷平,张建宁,杨新宇,朱涛,雪亮,刘辉,杨树源.利用基因芯片筛选人颅脑创伤皮层的差异表达基因[J].中华神经外科杂志,2007,23(7):490-492. 被引量：3
  • 2Saugstad JA. MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration[J]. J Cereb Blood Flow Metab, 2010, 30(9): 1564-1576.
  • 3Lei P, Li Y, Chen X, et al. Microarray based analysis ofmicroRNA expression in rat cerebral cortex after traumatic brain injury [J]. Brain Res, 2009, 1284: 191-201.
  • 4Dixon CE, Lyeth BG, Povlishock JT, et al. A fluid percussion model of experimental brain injury in the rat[J]. J Neurosurg, 1987, 67(1): 110-119.
  • 5Zindy F, Uziel T, Ayrault O, et al. Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors [J]. Cancer Res, 2007, 67(6): 2676-2684.
  • 6Chen J, Li Y, Wang L, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats [J]. Stroke, 2001, 32(4): 1005-1011.
  • 7Rink A, Fung KM, Trojanowski JQ, et al. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat [J]. Am J Pathol, 1995, 147(6):1575-1583.
  • 8Schmittgen TD. Regulation of microRNA processing in development, differentiation and cancer [J]. J Cell Mol Med, 2008, 12(5B): 1811-1819.
  • 9Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J]. Cancer Res, 2005, 65(14): 6029-6033.

共引文献9

同被引文献49

  • 1Hauptman N,Glavac D. MicroRNAs and long non - coding RNAs: Prospects in diagnostics and therapy of cancer [J]. Radio/ Oncol, 2013,47(4) :311 -318.
  • 2Shin S, Cha H J, Lee EM,et al. Alteration of miRNA profiles by iota- izing radiation in A549 human non - small cell lung cancer cells [ J]. International J Onco1,2009,35 ( 1 ) :81 - 86.
  • 3Iorio MV, Croce CM. MicroRNA dysregulation in cancer : Diagnos- tics, monitoring and therapeutics. A comprehensiw review [ J ]. EM- BO Mol Med,2012,4(3) :143 - 159.
  • 4Ma R, Jiang T, Kang X. Circulating microRNAs ire cancer: Origin, function[ J]. J Exp Clin Cancer Res,2012,31 (38) :25.
  • 5Friedman RC,Farh KK, Burge CB, et al. Most mammalian mRNAs are conserved targets of microRNAs [ J ] Genome Res, 2009, 19 ( 1 ) :92 - 105.
  • 6To KK. MicroRNA:A prognostic biomarker and a possible di'ngga- ble target for circumventing multidrug resistance in cancer chemo- therapy [ J ]. J Biomed Sci,2013,20 ( 99 ) : 1 - 20.
  • 7Bovell LC, Putcha BD, Samuel T, et al. Clinical implications of mi- croRNAs in cancer [ J ]. Bioteeh Histochem, 2013,88 ( 7 ) : 388 -396.
  • 8Schoof CR, Botelho EL, Izzotti A. MicroRNAs in cancer treatment and prognosis[ J]. Am J Cancer,2012,2(4) :414 -433.
  • 9Li L, Story M, Legerski RJ. Cellular responses to ionizing radiation damage [ J ]. Int J Radiat Oncol Biol Phys, 2001,49 ( 4 ) .. 1157 - 1162.
  • 10Yah D, Ng WL, Zhang X, et al. Targeting DNA - PKcs and ATM with miR - 101 sensitizes tumors to radiation [ J ]. PLoS ONE, 2010,5(7) :el 1397.

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中华神经医学杂志
2014年 第8期

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