达泊西汀治疗早泄的临床观察

Efficacy of Priligy on premature ejaculation:a clinical observation

目的了解达泊西汀（第一个被批准用于治疗早泄的药物）治疗中国男性早泄患者的疗效。方法本研究为前瞻性、开放的自身对照研究。收集2014年2～4月在我院门诊就诊的早泄患者，所有患者接受30mg×6粒达泊西汀治疗，4周后随访，记录患者用药情况及副作用，比较用药前后患者阴道内射精潜伏时间、评估早泄量表及临床总体印象评分的变化。结果应用临床总体印象评分，63．6％（21／33例）的患者报告有效；患者治疗前阴道内射精潜伏时间平均为0．88rain，治疗后平均为2．54min。副作用包括头晕、恶心、失眠、腹泻及射精困难，均轻微，可耐受。结论达泊西汀治疗中国早泄患者安全、有效。

To explore the efficacy of Priligy in the treatment of premature ejaculation （PE）. Methods Clinical data of PE patients treated with Priligy in our hospital during Feb. to Apr. 2014 were collected in this open and pro- spective studyy All patients received Priligy 30 mgX 6, the intra-vaginal ejaculation latency time （IELT）, premature ejaculation profile （PEP） before and after the therapy were recorded, and the clinical global impression of change （CGIC） was collected in the follow-up. Results A total of 63.6%0 PE patients were responsive to Priligy therapy. The IELT before treatment was 0.88 minutes, and increased to 2.54 minutes after therapy. The side-effect included dizziness, nausea, insomnia, diarrhea and ejaculatory difficulties, but they were mild and were well tolerated. Conclusions Priligy is effective and safe for Chinese PE patients.