中西医结合治疗高气道反应性慢性咳嗽合并月经失调临床观察

Clinical observation of integrated Chinese and western medicine in the treatment of chronic cough induced by airway hyperresponsiveness complicated with menstrual disorder

目的：探讨在高气道反应性慢性咳嗽合并月经失调患者中使用中西医结合治疗方法的效果。方法以我院2011年1月~2013年7月收治的高气道反应性慢性咳嗽合并月经失调患者110例为研究对象，随机分为A组与B组，所有患者均进行常规西医治疗，A组患者在此基础上，增加中医治疗方案。比较两组患者临床症状、肺功能、炎症因子水平和体内激素水平之间的差异。结果 A组患者治疗后咳嗽和月经失调中医症候积分分别为（2.13±0.89）分和（2.01±0.99）分，B组为（4.42±1.06）分和（3.48±1.02）分，A组显著低于B组（P＜0.05），A组治疗后FVC%、FEV1%和MMEF%分别为（112.27±4.49）、（112.17±9.47）和（75.58±5.51），显著高于B组（104.37±4.11）、（95.58±8.36）和（70.16±4.09），A组患者气道炎症反应强度低于B组，其体内E2、PRL和LH/FSH分别为（350.17±39.66）pmol/L、（0.98±0.18）nmol/L和（1.94±0.48）IU/L， A组患者PRL和LH/FSH显著低于B组（P＜0.05），E2显著高于B组（P＜0.05）。结论中西医结合可以有效治疗高气道反应性慢性咳嗽合并月经失调，其可有效改善患者临床症状，提高患者肺功能，降低患者气道炎症水平，调解患者体内激素水平。

Objective To analyse and discuss the curative effect of integrated Chinese and western medicine in the treatment of chronic cough induced by airway hyper-responsiveness complicated with menstrual disorder. Methods 110 patients with chronic cough induced by airway hyper-responsiveness complicated with menstrual disorder who were admitted to our hospital from January 2011 to July 2013 were selected as research subjects, and randomly allocated to group A and group B. All patients received regular treatment of western medicine, and patients in group A further received the treatment of traditional Chinese medicine. Clinical symptoms, pulmonary functions, levels of inflammatory factors and hormone levels between the two groups were compared. Results After the treatment, TCM symptom scores of coughing and menstrual disorder were（2.13±0.89） and（2.01±0.99） respectively in group A and（4.42±1.06） and（3.48±1.02） respectively in group B, and the scores in group A were significantly lower than those in group B（P 〈 0.05）. FVC%, FEV1% and MMEF% in group A after the treatment were（112.27±4.49）, （112.17±9.47） and（75.58±5.51） respectively, significantly higher than those of（104.37±4.11）,（95.58±8.36） and （70.16±4.09） respectively in group B. Intensity of airway inflammatory responses in group A was lower than that in group B,and E2,PRL and LH/FSH in group A were（350.17±39.66）pmol/L,（0.98±0.18）nmol/L and（1.94±0.48） IU/L respectively. PRL and LH/FSH in group A were significantly lower than those in group B（P 〈 0.05）, and E2 was significantly higher than that in group B（P 〈 0.05）. Conclusion Integrated Chinese and Western medicine is effective in the treatment of chronic cough induced by airway hyper-responsiveness complicated with menstrual disorder. It is effective in alleviating patients＇ clinical symptoms, improving patients＆#39; pulmonary functions, lowering patients＂ airway inflammatory responses and adjusting patients＂ hormone levels.