丙泊酚复合氯胺酮麻醉对碎石患者血清白细胞介素6的影响

Effects of Propofol Combined with Ketamine Anesthesia on Inflammatory Mediators Interleukin-6 in Percutaneous Nephrolithotomy Patients

目的:探讨丙泊酚复合氯胺酮麻醉对经皮肾镜碎石术患者血清白细胞介素6(IL-6)的影响。方法:将60例择期经皮肾镜取石术的全麻患者,分为丙泊酚组(P组)和丙泊酚复合氯胺酮组(PK组),各组30例,分别在麻醉诱导前(T1)、麻醉诱导后(T2)、手术开始后60 min(T3)及手术结束时(T4)采取静脉血,测定血清白介素-6(IL-6)的浓度。结果:2组在T1、T2时血清IL-6的浓度无明显差异(P>0.05),T3、T4时PK组均明显低于P组(P<0.05)。结论:丙泊酚复合氯胺酮麻醉,可有效减轻经皮肾镜碎石术患者血清IL-6释放、抑制炎性反应。

Objective To investigate the effects of propofol combined with ketamine anesthesia on inflammatory mediators interleukin-6（IL-6）in patients undergoing percutaneous nephrolithotomy（PCNL）. Methods Sixty patients undergoing percutaneous nephrolithotomy with general anaesthesia, were randomly assigned to two groups with 30 cases each： propofol group（group P） and propofol combined with ketamine group（group PK）. Venous blood samples were taken before anesthesia induction（T3）after induction of anesthesia（T2）,60 min after the start of operation（T3）and at the end of surgery（T4）from the two groups of patients, respectively, for determination of serum interleukin-6（IL-6） concentration. Results Compared with the group P, group PK showed no significant difference in serum concentrations of IL-6 at Tand T2（P 〉0.05） while serum concentrations of IL-6 in group RK were significantly lower than those in group P at T3 and T4（P〈0.05） Conclusion Propofol combined with ketamine anesthesia, can effectively reduce the release of IL-6 in patients with percutaneous nephrolithotomy, inhibiting inflammatory reactions.