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“双重打击”淋巴瘤的再认识 被引量：5

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摘要 “双重打出”淋巴瘤（double—hit lymphoma，DHL）是侵袭性B细胞淋巴瘤的一个暴因亚型。侵袭性B细胞淋巴瘤主要包括们綦特淋巴瘤（BL）、弥漫性大B细胞淋巴瘤（DLBCL）以及具有介于DLBCL和BL特点的无法分类的B细胞淋巴瘤（B—UNC／DLBcI／BL）。WHO（2008）造血与淋巴组织肿瘤分类将DHL放存B—UNC／DLBCL／BL的遗传学常节进行了介绍，因为DHL的发生率随年龄增长而增长，约处于30％的老年B—UNC／DLBCL／BL近年来DHL的研究逐渐增多，也有一些新的进展，有必要时其进行再认识。
作者 李向红
机构地区 北京大学肿瘤医院暨北京市肿瘤防治研究所病理科恶性肿瘤发病机制及转化研究教育部重点实验室
出处 《中华病理学杂志》 CAS CSCD 北大核心 2014年第8期505-507,共3页 Chinese Journal of Pathology
关键词 弥漫性大B细胞淋巴瘤 LYMPHOMA DLBCL 肿瘤分类 淋巴组织 侵袭性 HIT 遗传学
分类号 R733.1 [医药卫生—肿瘤]
  • 相关文献

参考文献12

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  • 5Pillai RK, Sathanoori M, Van Oss SB, et al. Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive, frequently extranodal lymphomas distinct from BCL2 double-hit B -cell lymphomas [ J ]. Am J Surg Pathol, 2013 37 ( 3 ) : 323-332.
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二级参考文献48

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  • 10Li S, Lin P, Fayad LE, et al. B-cell lymphomas with MYC/8q24 rearrangements and IGH @ BCUlt ( 14; 18) ( q32; q21 ): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome. Mod Pathol, 20 12 ,25 (1) : 145-156.

共引文献14

同被引文献25

  • 1Malassez M. Lymphadenome du testicle[ J]. Bull Soc Anta (Par- is), 1877,52(2) :176 -8.
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  • 6Fox C. Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus eyelophosphamide,doxorubiein, vincristine, and prednisone [ J ]. J Clin Oncol, 2012, 30(28) :3452 -9.
  • 7Shimin H, Xu-Monette Z Y, Alexander T, et al. MYC/BCL2 pro- tein coexpression contributes to the inferior survival of activated B- cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures : a report from the international DLBCL rituximab-CHOP consortium program [ J]. Blood, 2013,121 (20) :4021 - 1.
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  • 9王国平,郗彦凤,李义,王晋芬,白纬.bcl-2与bcl-6在弥漫性大B细胞淋巴瘤中表达的研究[J].白血病．淋巴瘤,2009,18(10):588-591. 被引量：9
  • 10黄慧,杨文萍.介于弥漫大B细胞淋巴瘤和伯基特淋巴瘤之间的未分类的B细胞淋巴瘤的临床病理诊断进展[J].临床与实验病理学杂志,2010,26(2):227-230. 被引量：6

引证文献5

二级引证文献18

中华病理学杂志
2014年 第8期

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