酒精成瘾者静息态缺省模式网络fMRI

fMRI of default mode network in alcohol addicts

目的应用静息态fMRI观察酒精成瘾者缺省模式网络(DMN)改变。方法对30例酒精成瘾者(酒精成瘾组)及30名性别、年龄、受教育程度及尼古丁依赖程度相匹配的健康志愿者(对照组)进行静息态fMRI扫描,采取独立成分分析方法提取DMN,对两组DMN进行统计分析。结果相对于对照组,酒精成瘾组DMN在右楔前叶、左小脑脚Ⅱ区功能连接减低,而在左后扣带回、右颞中回、右颞上回及右楔前叶区域功能连接增强。结论酒精成瘾者DMN功能异常。静息态功能MR成像揭示酒精成瘾复杂神经机制具有一定的价值。

Objective To explore the characteristics of default mode network（DMN）in alcohol addicts.Methods Thirty alcohol addicts and thirty age,gender,the extent of education and nicotine dependence matched controls were experienced rest fMRI scans in 3.0TMRI scanner,while the BOLD signal was acquired to calculate independent component analysis to extract the DMN,then the differences were analyzed.Results In contrast to controls,the alcohol addicts showed reduced DMN connectivity in the right precuneus and left cerebellum crusⅡ,while enhanced connectivity in the left posterior cingulate,right middle temporal gyrus,right superior temporal gyrus and right precuneus.Conclusion The function of DMN is abnormal in alcohol addicts.The rest fMRI have a certain extent of value to expose the complicated neuromechanism of alcohol addiction.