抽动秽语综合征的扩散张量成像和功能磁共振成像研究进展

Progresses of diffusion tensor imaging and functional magnetic resonance imaging in Tourette syndrome

抽动秽语综合征(TS)是一种儿童期发病的神经精神疾患,临床主要表现为多发性运动性和发声性抽动。病理生理学研究结果支持TS患者皮层-纹状体-丘脑-皮层(CSTC)环路可能存在着功能障碍。基于DTI的形态学研究显示,脑白质异常不仅局限于运动通路,躯体感觉通路、边缘系统等同样受累。任务态fMRI研究显示,TS患者存在功能代偿机制。静息态fMRI研究显示,TS患者皮层-基底核网络存在功能障碍。本文对TS的扩散张量成像和fMRI研究进展进行综述。

Tourette syndrome（TS）is a neuropsychiatric disorder with childhood onset characterized by chronic motor and vocal tics.The pathophysiology of TS reveales the dysfunction of cortico-striato-thalamo-cortex circuit（CSTC）.Diffusion tensor imaging（DTI）based morphometry revealed white matter abnormality is not restricted to motor pathways alone,but also somatosensory system,limbic system and so on.The results of task-related fMRI reflect the presence of compensatory mechanism to functional disturbances.The results of resting-state fMRI suggest functional immaturity of corticobasal ganglia networks in Tourette syndrome.The development of DTI and fMRI in TS was reviewed in this article.