多效生长因子在消化系肿瘤中的表达及意义

The expression and significance of pleiotrophin in the tumors of digestive system

多效生长因子(pleiotrophin,PTN)是分泌性肝素结合细胞因子,PTN基因作为一个原癌基因,与肿瘤的发生和发展关系密切。PTN可分泌到细胞外液(包括血液)中,与肝素具有高亲和性。PTN在细胞分裂、血管生成、神经系统发育和神经系统损伤性疾病以及肿瘤等方面均有作用。近年来研究表明PTN在肿瘤的发生和发展中起着重要的作用,PTN高表达于大多数肿瘤中,尤其是消化系统肿瘤,其表达水平可以作为肿瘤诊断、治疗、预后评价的指标。本文结合国内外文献对PTN在消化系统肿瘤的表达水平及其意义作一概述。

Pleiotrophin （PTN） is a secreted heparin-binding cytokine. The PTN gene as a proto-oncogene is closely I related to occurrence and development of tumors. PTN can be secreted into the extracellular fluid （including blood） , and has a high affinity to heparin. PTN has effect in many conditions, including cell division, angiogenesis, nervous system development, nervous system tramatic disease and tumor, etc. Recent studies have shown that PTN is highly ex- pressed in most tumors and plays an important role in tumor occurence and development, especially in tumors of the di- gestive system. Expression level of PTN can be used in tumor diagnosis and evaluation of treatment and prognosis. In this artical, PTN expression in tumors of the digestive system and its significance are reviewed.