675例肝脏穿刺活检的肝细胞脂肪变性分析

Hepatic steatosis in 675 cases of liver biopsy pathology

目的通过对675例肝脏穿刺病理结果的回顾性研究,分析各种肝脏疾病的肝细胞脂肪变性情况。方法收集西京医院2008年7月-2011年9月进行的675例肝脏穿刺活检的病理结果,分析其病理诊断及脂肪变性的构成比,肝细胞脂肪变性的发生率,以及肝细胞脂肪变性与血清甘油三酯的相关性。结果 72.6%(490/675)的肝脏穿刺患者为肝肿瘤或瘤样变、自身免疫性肝病、慢性病毒性肝炎及肝硬化。15.7%(106/675)患者存在不同程度的肝细胞脂肪变性,其中49.1%(52/106)的患者为肝硬化、病毒性肝炎及肝损害,33.0%(35/106)患者为酒精性/非酒精性脂肪肝。肝硬化患者发生肝细胞脂肪变性的比率高达30.7%。结论肝细胞脂肪变性普遍存在于各种慢性肝脏损害性疾病,尤其是肝硬化合并肝细胞脂肪变性的比率高达30.7%,需要在临床诊治过程中高度重视。

Objective To analyze the hepatic steatosis according to the liver biopsy pathology results of 675 cases. Methods Six hundred and seventy-five cases of liver biopsy pathology results were collected from Jul. 2008 to Sep. 2011 to analyze the feature of the pathological diagnosis and hepatic steastosis, and the incidence of hepatic cell steatosis in various liver diseases. Results The result showed that 72.6% patients with liver puncture were liver tumors or tumor-like changes, autoimmune liver disease, chronic viral hepatitis and cirrhosis. 15.7% patients had hepatic steato- sis, of which 49.10% patients were liver cirrhosis, viral hepatitis and liver damage, alcoholic/non-alcoholic fatty liver disease accounted for 33.0%. The steatosis rate of cirrhosis was up to 30.7%. Conclusion Hepatic steatosis was commonly found in various chronic liver damage diseases. The ratio of liver cirrhosis complicated with hepatic steatosis was 30.7%. So we should pay high attention on hepatic steatosis in clinical diagnosis and treatment.