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基于mPTP对心肌缺血/再灌注损伤干预研究

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摘要 线粒体通透性转移孔在心肌缺血再灌注损伤中具有重要作用,抑制mPTP开放对I/R损伤的心脏具有保护作用。本文就近年来心肌I/R中基于mPTP开放的干预研究做一综述。
作者 李静远 黄秀兰
机构地区 中央民族大学中国少数民族传统医学国家民委-教育部重点实验室
出处 《医学研究杂志》 2014年第8期175-177,共3页 Journal of Medical Research
基金 国家自然科学基金资助项目(81173656) 国家民族事务委员会基金资助项目(10ZY08)
关键词 心肌缺血 再灌注损伤 线粒体通透转移孔 心脏保护
分类号 R3 [医药卫生—基础医学]
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参考文献21

  • 1Lee J,Giordano S,Zhang J.Autophagy,mitochondria and oxidative stress:cross-talk and redox signalling[J] .Biochem J,2012,441(2):523-540.
  • 2Fantinelli JC,Pérez Nú(n)ez IA,González Arbeláez LF,et al.Participation of mitochondrial permeability transition pore in the effects of ischemic preconditioning in hypertrophied hearts:role of NO and mitoK (ATP)[J] .IntJCardiol,2013,166(1):173-180.
  • 3Pasdois P,Parker JE,Griffiths E J,et al.The role of oxidized eytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia[J] .Biochem J,2011,436(2):493-505.
  • 4Sato M,Yokoyama U,Fujita T,et al.The roles of cytochrome p450 in ischemic heart disease[J] .Curr Drug Metab,2011,12 (6):526-532.
  • 5Lemasters JJ,Theruvath TP,Zhi Z,et al.Mitochondrial Calcium and the permeability transition in cell death[J] .Biochim Biophys Acta,2009,1787(11):1395-1401.
  • 6Penna C,Perrelli MG,Pagliaro P.Mitochondrial pathways,permeability transition pore,and redox signaling in cardioprotection:therapeutic implications[J] .Antioxid Redox Signal,2013,18 (5):556-599.
  • 7冯阳,刘建军,黄钢.线粒体膜通透性转换孔结构与功能研究进展[J].上海交通大学学报（医学版）,2012,32(3):356-360. 被引量：19
  • 8Park J,Choi C.Contribution of mitochondrial network dynamics to intracellular ROS signaling[J] .Commun Integr Biol,2012,5 (1):81-83.
  • 9Javadov SA,Clarke S,Das M,et al.Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart[J] .J Physiol,2003,549(Pt 2):513-524.
  • 10Gomez L,Li B,Mewton N,et al.Inhibition of mitochondrial permeability transition pore opening:translation to patients[J] .Cardiovasc Res,2009,83(2):226-233.

二级参考文献32

  • 1Kinnally KW,Peixoto PM,Ryu SY,et al.Is mPTP the gate keeperfor necrosis,apoptosis,or both?[J]Biochim Biophys Acta,2011,1813(4):616-622.
  • 2Haworth RA,Hunter DR.The Ca2+-induced membrane transitionin mitochondria II.Nature of the Ca2+trigger site[J].ArchBiochem Biophys,1979,195(2):460-467.
  • 3Joza N,Susin SA,Daugas E,et al.Essential role of the mitochon-drial apoptosis-inducing factor in programmed cell death[J].Nature,2001,410(6828):549-554.
  • 4Wang X,Yang C,Chai J,et al.Mechanisms of AIF-mediatedapoptotic DNA degradation in caenorhabditis elegans[J].Science,2002,298(5598):1587-1592.
  • 5Lartigue L,Kushnareva Y,Seong Y,et al.Caspase-independentmitochondrial cell death results from loss of respiration,not cytotoxicprotein release[J].Mol Biol Cell,2009,20(23):4871-4884.
  • 6Kokoszka JE,Waymire KG,Levy SE,et al.The ADP/ATP translo-cator is not essential for the mitochondrial permeability transitionpore[J].Nature,2004,427(6973):461-465.
  • 7Baines CP,Molkentin JD.Adenine nucleotide translocase-1 inducescardiomyocyte death through upregulation of the pro-apoptotic proteinBax[J].J Mol Cell Cardiol,2009,46(6):969-977.
  • 8Baines CP,Kaiser RA,Sheiko T,et al.Voltage-dependent anionchannels are dispensable for mitochondrial-dependent cell death[J].Nat Cell Biol,2007,9(5):550-555.
  • 9Chiara F,Castellaro D,Marin O,et al.Hexokinase II detachmentfrom mitochondria triggers apoptosis through the permeability transi-tion pore independent of voltage-dependent anion channels[J].PLoS One,2008,3(3):e1852.
  • 10Han D,Antunes F,Canali R,et al.Voltage-dependent anion chan-nels control the release of the superoxide anion from mitochondria tocytosol[J].J Biol Chem,2003,278(8):5557-5563.

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医学研究杂志
2014年 第8期

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