胰岛素低血糖合并药物治疗抑郁症的临床疗效观察

Observation of clinical efficacy of insulin hypoglycemia combined with drug treatment for depression

目的:探讨胰岛素低血糖合并药物治疗抑郁症的临床疗效及安全性。方法:选择108例符合CCMD-3关于抑郁症的诊断标准的患者,按入院时间随机将患者分为研究组及对照组各54例,疗程为1个月。对照组患者使用常规药物治疗,研究组患者联用胰岛素低血糖治疗。于患者治疗前,治疗后1、2、4周末采用汉密尔顿抑郁量表,不良反应量表评定疗效及不良反应。结果:两组患者的治疗均有效,但研究组患者起效时间明显优于对照组,研究组患者的有效率70.37%,明显高于对照组的51.85%,差异有统计学意义(P<0.05)。两组患者治疗过程中出现的不良反应无明显差异。结论:胰岛素低血糖辅助治疗抑郁症,起效快,疗效更为显著,不增加不良反应。

Objective：To investigate safety and clinical efficacy of insulin hypoglycemia combined with drug treatment for depression. Methods：A total of 108 cases meeting CCMD- 3 criteria for depression were selected. According to the admission time,they were randomly divided into study group and control group,each with 54 cases,and accepted a 1 month＇s treatment. The cases in control group received the routine medicine,while those in study group received insulin hypoglycemia combined with drug treatment.Hamilton depression scale（HAMD） and treatment emergent symptom scale（ TESS） were used before and 1,2,4 weeks after the treatment to assess the efficacy and adverse reactions. Results： The treatments of the two groups were effective,but the onset time of study group was superior than that of control group. The effective rate of study group（70. 37%） was significantly higher than that of control group（51. 85%）,and the difference was statistically significant（P〈0. 05）. There were no significant differences in the adverse reactions during the treatment between the two groups. Conclusions： Insulin hypoglycemia in the adjuvant treatment of depression has a rapid onset,more significant effect,and no increase in the adverse reactions.