补肾通督胶囊对胶原诱导关节炎大鼠的免疫调控作用

Immunoregulative Effect of Bushen Tongdu Capsule on Arthritis Rats Induced by Collagen

目的:研究补肾通督胶囊对CIA大鼠的免疫调控作用。方法:将大鼠分为正常对照组、模型组、补肾通督胶囊(BS)低剂量组、中剂量组、高剂量组和雷公藤组,接受相应治疗。结果:BS对脾脏、外周血淋巴细胞有调控作用,对血清IL6和Ⅱ型胶原蛋白抗体的水平有抑制作用。结论:补肾通督胶囊对外周血淋巴细胞的调控作用效果显著。

Objective： To investigate the effect of Bushen Tongdu capsules on arthritis rats induced by collagen .Methods：Rats were randomly assigned into six groups , normal control（C）, model（M）, low dose of BS（BSL）, medium dose （BSM）, high dose（BSH）,tripterygium glycosides （TG） groups and they were treated.Results： Bushen Tongdu cap-sules could relieve hyperplasia of spleen white pulp , modulate peripheral lymphocytes, IL -6 and coll -II antibody. Conclusion： Bushen Tongdu capsules are effective on modulation of peripheral lymphocyte functions .