帕瑞昔布钠在胸腰椎骨折患者术后镇痛的疗效分析被引量：2

下载PDF

导出

摘要目的观察帕瑞昔布钠在胸腰椎骨折术后镇痛的临床疗效。方法将全麻下行胸腰椎单椎体骨折后路减压复位内固定手术患者52例随机分为A组和B组,A组术后予静脉注射帕瑞昔布钠注射液40mg,B组予肌肉注射曲马多注射液100mg,比较两组的起效时间、各时点镇痛视觉模拟评分以及不良反应。结果 A组镇痛起效时间(11.36±5.63)min,B组镇痛起效时间(17.27±8.75)min,两组差异有统计学意义(P<0.05)。各时点镇痛效果视觉模拟评分A组低于B组,A组镇痛效果较佳(P<0.05)。两组不良反应发生率A组优于B组(P<0.05)。结论帕瑞昔布钠能够有效缓解胸腰椎骨折术后疼痛,是静脉注射镇痛的合适用药。

作者何立江吴世强

机构地区福建医科大学附属第二医院骨科

出处《福建医药杂志》 CAS 2014年第4期113-114,共2页 Fujian Medical Journal

关键词帕瑞昔布钠胸腰椎骨折术后镇痛

分类号 R614 [医药卫生—麻醉学]

引文网络
相关文献

参考文献8

1Perk N M, Keh L H. Chronic pain as an outcome of surgery: a review of predictive factors [J]. Anesthesiology, 2003, 93 (5): 1123-1133.
2Volk T, Schenk M, Volgt K, et al. Postoperative epidural an- esthesia preserves lymphocyte, but not monocyte, immune func- tion after major spine surgery[J]. Anesth Analg, 2004, 98(4): 1086-1092.
3Svensson C I, Yaksh T L. The spinal phospholipase-cyclooxyge- nase prostanoid cascade in nociceptive processing [J]. Annu Rev Phammcol Toxicol, 2002, 42 (16): 553-558.
4Cheer S M, Goa K L. Pareeoxib (Parecib Sodium) [J]. Drugs, 2001, 61 (8): 1133-41.
5吴新民,岳云,张利萍,王俊科,艾登滨,于布为,薛张纲,黄文起.术后镇痛中帕瑞昔布钠对吗啡用量的节俭作用和安全性—前瞻性、多中心、随机、双盲、安慰剂对照、平行分组研究[J].中华麻醉学杂志,2007,27(1):7-10. 被引量：367
6黄伟.塞来昔布在骨科围手术期超前镇痛中的作用[J].国际骨科学杂志,2010,31(6):374-375. 被引量：8
7柯超群,陈彦青.帕瑞昔布钠超前镇痛对腹腔镜胆囊切除术后疼痛的影响[J].福建医药杂志,2010,32(5):134-135. 被引量：4
8Hubbard R C, Naumann T M, Traylor L, et al. Parecoxib so dium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia [J]. Br J Anaesth, 2003, 90 (1): 166-172.

二级参考文献23

1徐建国.疼痛药物治疗学[M].北京:人民卫生出版社,2007:264-275.
2Katz J.George Washington Crile,anoci-association,and pre-emptive analgesia.Pain,1993; 53(3):243-245.
3Wall PD.The prevention of postoperative pain.Pain,1988; 33(3):289-290.
4Moiniche S,Kehlet H,Dahl JB,et al.A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief:the role of timing of analgesia.Anesthesiology,2002; 96(3):725-741.
5Ong KS,Lirk P,Seymour RA,et al.The efficacy of preemptive analgesia for acute postoperative pain management:a meta-analysis.Anesth Analg,2005; 100(3):757-773.
6Dahl JB,Moiniche S.Pre-emptive analgesia.Br Med Bull,2004; 71:13-27.
7Ekman EF,Wahba M,Ancona F.Analgesic efficacy of perioperative celecoxib in ambulatory arthroscopic knee surgery:a double-blind,placebo-controlled study.Arthroscopy,2006; 22(6):635-642.
8McArdle P. Intravenous analgesia. Crit Care Clin, 1999,15:89-104.
9Bowdle TA. Adverse effects of opioid agonists and agonist-antagonists in anesthesia. Drug Saf, 1998,19:173-189.
10Kehlet H, Dahl JB. The value of "multimodal" or "balanced analgesia"in postoperative pain treatment. Anesth Analg, 1993,77:1048-1056.