摘要
目的探讨非急性感染期肺脾气虚证、脾虚肝旺证复感儿与免疫球蛋白(IgA、IgG、IgM)和T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)等免疫指标的相关性,为不同证型的复感儿提供微观辨证指标,以促进中医辨证理论的现代化研究。方法检测150例肺脾气虚证和150例脾虚肝旺证复感儿非急性感染期血清IgA、IgG、IgM及CD3+、CD4+、CD8+、CD4+/CD8+等水平,另选220例健康儿童作为对照分析。结果 1与健康儿童对照组相比较,肺脾气虚证和脾虚肝旺证复感儿IgA和IgG水平均降低(P<0.05),CD4+细胞百分率降低(P<0.05),CD8+细胞百分率增高(P<0.05),CD4+/CD8+比值降低,且具有统计学意义(P<0.01),其余指标均无统计学意义(P>0.05);2两中医证型组组间相比较,免疫球蛋白和T淋巴细胞亚群等微观指标均无统计学意义(P>0.05)。结论肺脾气虚证、脾虚肝旺证复感儿非急性感染期体液免疫功能低下,细胞免疫功能紊乱,肺脾气虚证、脾虚肝旺证复感儿与免疫球蛋白、T淋巴细胞亚群等免疫指标间存在一定关联,但不具备正负相关性。
Objective To study the relationship of immunoglobulins(IgA,IgG,IgM)、T cell subsets(CD3+,CD4+,CD8+,CD4+/CD8+)and children with recurrent respiratory infection in the Lung-spleen-qi-deficiency,spleen-deficiency-hyperactive-liver-fire.Methods We detected 150 cases in the Lung-spleen-qi-deficiency and 150 cases in the spleen-deficiency-hyperactive-liver-fire of RRTI in no nacute infection period of serum IgA,IgG,IgM and CD3+,CD4+,CD8+,CD4+/CD8+level. A total of 220 children were selected as health control group. Results ① Compared with healthy control group,the level of IgA,IgG and CD4+cells in the different types of RRTI group decreased(P〈0.05),the percentage of CD8+cells increased(P〈0.05),CD4+/CD8+ratio decreased,and there was a significant difference(P〈0.01). No significant differences were foud in other indexes(P〉0.05). ②Compared with the two Chinese medicinesyndromes,the level of IgA,IgG,IgM,CD3+,CD4+,CD8+and CD4+/CD8+showed no significant difference(P〉0.05).Conclusion In children of recurrent respiratory tract infection(non-acute infection period),the syndrome type of traditional Chinese medicine and immune globulin,T cell subsets in microcosmic indexes have a certain correlation,but no significant positive or negative correlation.
出处
《云南中医学院学报》
2014年第4期48-50,54,共4页
Journal of Yunnan University of Traditional Chinese Medicine
基金
浙江省中医药科学研究基金(2012ZA065)
关键词
复感儿
肺脾气虚证
脾虚肝旺证
免疫指标
recurrent respiratory tract infection
the Lung-spleen-qi-deficiency
the spleen-deficiency-hyperactive-liverfire
immune indexes