血府逐瘀汤对冠心病同型半胱氨酸水平影响的研究

Clinical Observation of Xuefu Zhuyu Decoction Effect on Homocysteinemia of Coronary Artery Disease

目的探讨血府逐瘀汤对冠心病伴高同型半胱氨酸(Hcy)血症患者的血清Hcy水平的影响。方法冠心病高同型半胱氨酸血症患者80例,随机分为叶酸组40例和血府逐瘀汤组40例,用药前后测定血浆Hcy水平。结果血府逐瘀汤组总有效率为95.0%,明显优于叶酸组的70%(P<0.05);叶酸组在西医常规治疗基础上,加予口服叶酸,随访3个月后Hcy水平较前下降,有统计学意义(P<0.05),血府逐瘀汤组在西医常规治疗的基础上,予以口服血府逐瘀汤,随访3个月后Hcy水平较前明显下降,有统计学意义(P<0.05),2组治疗后Hcy水平比较有统计学意义(P<0.05),血府逐瘀汤较之叶酸组有更为显著的下降(P<0.05)。结论血府逐瘀汤可明显降低冠心病高Hcy血症患者的血浆Hcy水平。

Objective To study the intervention function of Xuefu Zhuyu Decoction on the level of Hcy in plasma of coronary artery disease. Methods 80 patients with Hyperhomocysteinemia of coronary artery disease were divided into folic acid group（40cases） and Xuefu Zhuyu Decoction group（40 cases）The levels of Hcy in plasma were determined before and after being treated.Results The total response rate in the Xuefu Zhuyu Decoction group was 95. 0%,which was significantly higher than 70. 0% in the folic acid group（P〈0.05）. After being treated,the levels of Hcy in plasma in the folic acid group（40 cases）and Xuefu Zhuyu Decoction group decreased significantly（P〈0.05）.After the treatment in the three groups by analysis of variance was statistically significant（P〈0.05）,Xuefu Zhuyu Decoction group than in the folic acid group were more obvious changes,there was statistical significance（P〈0.05）. Conclusion Xuefu Zhuyu Decoction could obviously decrease the plasma Hcy levels in patients with coronary heart disease of high Hyperhomocysteinemia.