血清EPCA-2与FPSA/TPSA值在前列腺癌诊断的关系

The effects of serum EPCA-2 and FPSA/TPSA values on the diagnosis of prostate cancer

目的:探讨血清早期前列腺癌抗原-2(Early Prostate Cancer Antigen,EPCA-2)、游离型/总PSA(F/TPSA)在前列腺癌(PCa)诊断中的临床应用价值。方法:用酶联免疫吸附测定法(ELISA)分别对前列腺癌组与良性前列腺增生组患者血清进行检测EPCA-2值、F/TPSA值及PSA值,所得数据的分析和处理采用SPSS17.0统计学软件进行。结果:(1)前列腺癌组PSA水平显著高于BPH组,差异有统计学意义(P<0.01)。(2)前列腺癌组FPSA/TPSA水平比值显著低于BPH组,差异有统计学意义(P<0.01)。(3)前列腺癌组EPCA-2水平为(63.45±23.49)ng/mL,而BPH组EPCA-2水平为(16.60±7.62)ng/mL,较前列腺癌组明显为低,差异具有统计学意义(P<0.01)。(4)诊断能力EPCA-2>FPSA/TPSA>PSA。(5)FPSA/TPSA水平与EPCA-2水平之间无相关关系。(6)若将EPCA-2与FPSA/TPSA比值联合应用预测前列腺癌的特异性为90.00%,敏感性为95.00%。结论:EPCA-2、FPSA/TPSA、PSA三者相比在诊断前列腺癌方面的能力排名为EPCA-2>FPSA/TPSA>PSA,并且EPCA-2与FPSA/TPSA比值之间无相关性。若将EPCA-2与FPSA/TPSA比值联合应用在前列腺癌诊断方面可大大提高诊断率,降低活检率。

Objective：To explore the clinical application value of EPCA-2,F/TPSA in the diagnosis of prostate cancer.Methods：Serum EPCA-2value,F/TPSA value,and PSA value of patients with prostate cancer and benign prostatic hyperplasia were detected by enzyme linked immunosorbent assay,respectively.The data were analyzed and processed by SPSS17.0statistical software.Results：（1）The level of PSA in prostate cancer group was significantly higher than that in BPH group,and the difference was statistically significant（P〈0.01）.（2）The level of FPSA/TPSA in Prostate cancer group was significantly lower than that in BPH group,and the difference was statistically significant（P〈0.01）.（3）EPCA-2level in prostate cancer group was（63.45±23.49）ng/mL;while it was（16.60±7.62）ng/mL in BPH group.The level in prostate cancer group was significantly higher than that in BPH group,and the difference was statistically significant（P〈0.01）.（4）Diagnostic capabilities were：EPCA-2〉FPSA/TPSA〉PSA.（5）There was not any correlation between FPSA/TPSA level and EPCA-2 levels.（6）If EPCA-2value and FPSA/TPSA ratio were combined to diagnose prostate cancer,the specificity was of 90.00%,the sensitivity of 95.00%.Conclusions：Sort diagnostic capabilities are：EPCA-2〉FPSA/TPSA〉PSA.No correlation was existed between EPCA-2value and FPSA/TPSA ratio.The application of both EPCA-2level and FPSA/TPSA ratio in the diagnosis of prostate cancer can greatly improve diagnostic rate of prostate cancer,and reduce biopsy rate.