固相研磨反应在缩合反应中的应用

Application of Solid Phase Grinding Method in Condensation Reaction

固相研磨有机合成方法比传统的有机合成方法方便,易操作。在研磨条件下许多传统的反应可以在较温和的条件下进行,能有效的提高收率或反应的选择性。本文主要综述了固相研磨反应在Knoevenagel缩合、醇醛缩合、wittig缩合、Biginelli缩合、希夫碱缩合等缩合反应中的应用。

Compared with the traditional methodology,solid phase grinding method can be operated conveniently and easily. With solid phase grinding method,some traditional organic reaction can be performed under mild condition in higher yield or in better selectivity. The applications of solid phase grinding method in Knoevenagel condensation,aldol reaction,wittig reaction,Biginelli condensation and Schiff base condensation reaction were highlighted.