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骨形成蛋白信号通路在胸腺T细胞分化发育中的作用

Role of bone morphogenetic protein signal pathway in T lymphocyte differentiation and development
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摘要 骨形成蛋白(bone morphogenetic protein,BMP)是转化生长因子-β(transforming growth factor-β,TGF-β)家族成员中最大的一族,因其能在异位诱导骨和软骨形成而得名。BMP信号通路不仅在胚胎发育过程中发挥关键作用,其在促进胸腺的发育和T细胞分化发育中也发挥着重要的作用。本文对BMP信号通路及其对胸腺T细胞分化发育影响的最新研究进展作一综述。 Bone morphogenetic protein （BMP） is the biggest and well known member of transforming growth factor- β（TGF- β ） family because they can induce bone and cartilage formation. BMP signal pathway plays an important role not only in embryonic development but also in thymus development and T cell differentiation and development. Following is a review of the recent advances in BMP signaling pathway and its role in T cell differentiation and development.
作者 冯小兵 李月敏 李杨
机构地区 解放军第 军事医学科学院放射与辐射医学研究所
出处 《解放军医学院学报》 CAS 2014年第9期961-963,共3页 Academic Journal of Chinese PLA Medical School
基金 中国博士后科学基金特别资助项目(201003778)~~
关键词 骨形成蛋白 信号通路 T细胞 胸腺细胞 分化发育 bone morphogenetic protein signaling pathway T cells thymocytes differentiation and development
分类号 R392.12 [医药卫生—免疫学]
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参考文献33

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二级参考文献22

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解放军医学院学报
2014年 第9期

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