直肠癌骨转移患者核素骨显像特征及多因素分析

Multiple factors analysis and radionuclide bone imaging characteristics of colorectal cancer patients with bone metastases

目的探讨直肠癌骨转移患者核素骨显像特征及预后因素。方法回顾性分析2007年12月～2010年12月经病理检查确诊为直肠癌且核素全身骨显像诊断为骨转移的121例患者的临床资料，通过单因素分析和多因素Cox回归模型分析患者年龄、首诊临床分期、原发灶手术、原发灶放化疗、骨转移灶数目、骨转移伴其他脏器转移与患者预后的关系。结果单因素分析结果显示，患者年龄（P=0．022）、首诊临床分期（P＜O．001）、原发灶手术（P＜O．001）、骨转移伴其他脏器转移（P＜O．001）的生存率均有差异，其余各项无差异（P＞O．05）。多因素分析结果显示，患者年龄（P=0．028）、首诊临床分期（P=0．031）、原发灶手术（P=0．044）、骨转移伴其他脏器转移（P=0．017）是影响直肠癌患者预后的主要因素。结论患者年龄、首诊临床分期、原发灶手术、骨转移伴其他脏器转移是影响直肠癌患者预后的主要因素。

Objective To identify bone scintigraphy features and prognostic factors in colorectal cancer patients with bone metastases. Methods The clinical data of 121 cases of colorectal cancer patients with bone metastases were collected and retrospectively analyzed. The univariate analysis and multivariate analysis were used to analyze the relationship between age, first diagnosed clinical stage, primary tumor surgery, primary tumor chemotherapy, the number of bone metastasis, metastasis to bone and other organs and prognosis. Results in univariate analysis, the age（P=0. 022）, first diagnosed clinical stage（P〈0. 001）, primary tumor surgery（P〈0. 001 ）, metastasis to bone and other organs （P〈0. 001）were prognosis factors. In multivariate analysis, the age（P = 0. 028）, first diagnosed clinical stage（ P= 0. 031 ）, primary tumor surgery（P = 0. 044）, metastasis to bone and other organs （P = 0.017） were prognosis factors. Conclusion Patient age, first diagnosed clinical stage, primary tumor surgery, metastasis to bone and other organs are the major fac- tor affecting the prognosis of patients with colorectal cancer.