AFU、PT、Cp、T_4联合检测在乙型肝炎患者中的临床意义

Detection of AFU,PT,Cp and T_4 in Patients with Hepatitis B Disease and Its Clinical Significance

目的探讨乙型肝炎患者血清甲状腺素(T4)、铜蓝蛋白(Cp)、α-L-岩藻糖苷酶(AFU)和凝血酶原时间(PT)水平变化与肝功能损害程度的相关性及其临床意义。方法 187病例分成慢性肝炎组、重型肝炎组和肝硬化组,同时选择同期进行体检的健康人作为对照组,分别检测T4、Cp、AFU和PT,并进行统计学分析。结果各病例组AFU、PT和T4与正常对照组比较,差异均具有统计学意义(P<0.05);肝硬化组AFU明显低于其他两个病例组(P<0.01);各病例组PT之间差异均具有统计学意义(P<0.05);慢性肝炎组T4高于其他病例组(P<0.05);重型肝炎组Cp低于正常对照组及其他病例组(P<0.05),但慢性肝炎组和肝硬化组Cp与正常对照组之间无显著性差异(P>0.05)。结论联合检测T4,Cp,ALT和PT对病毒性肝炎的早期和鉴别诊断、病情判断以及疗效和预后评估有重要参考价值。

Objective To explore the changes of levels of thyroxine （T4）, ceruloplasmin （Cp）,α-L- fucosidase （AFU）, prothrombin time （PT）, the correlation with liver function damage degree and its clinical significance. Methods 187 cases （cases group） were divided into chronic hepatitis group （n = 104）, severe hepatitis group （n = 43） and liver cirrhosis group （n = 40）, and 168 cases of healthy people were selected as the control group. The levels of T4, Cp, AFU and PT of all groups were detected. Results Compared with the control group, the levels of AFU, PT and T4 of chronic hepatitis group, severe hepatitis group and liver cirrhosis group were statistically different （all P〈0.05）. The level of AFU of liver cirrhosis group was significantly lower than that of chronic hepatitis group and severe hepatitis group （both P〈0.01）. The differences of levels of PT among chronic hepatitis group, severe hepatitis group and liver cirrhosis group were statistically significant （P 〈0.05）. The level of T4 of chronic hepatitis group was significantly higher than that of severe hepatitis group and liver cirrhosis group （both P 〈0.05）. The level of Cp of severe hepatitis group was significantly lower than that of the control group, chronic hepatitis group and liver cirrhosis group （P〈0.05）, but there was no statistical difference in the level of Cp between chronic hepatitis group and control group, liver cirrhosis group and control group （both P〉0.05）. Conclusions The combined detection of T4, Cp, ALT and PT has important value in the early diagnosis, differential diagnosis, and estimation of disease condition and prognosis of viral hepatitis