摘要
β-肾上腺素受体所介导的经典G蛋白通路在心功能的调节中发挥着重要的作用,参与调节心肌收缩以及心肌细胞肥大等过程。近年来的研究发现,β-arrestin与β-肾上腺素受体的脱敏、内化、再循环以及降解密切相关,并可以通过其桥梁作用,使受体与多条信号通路之间建立联系。此外,β-arrestin还可以进入细胞核或者通过NF-kB/ERK进而参与表达水平的调控。鉴于β-arrestin与β-肾上腺素受体的密切关系及其本身作用的多样性,对它的深入研究将有助于新一代G蛋白偶联受体药物的研发。
β-adrenergic receptor mediated classic signaling play an essential role in regulating contraction and hypertrophy of myocardium. β-arrestin were identified as mediators of G protein-coupled receptor（GPCR） desensitization, endocytosis and recycle. However, it is now clear that they integrate receptors with many intracellular signaling networks. Moreover, β-arrestin also translocate into nucleus or assist translocation of NFkB/ERK into the nucleus and activation of transcription. The involvement of arrestins in many discrete developmental signaling events suggests a potential role in the development of new types of GPCR drugs.
出处
《中国分子心脏病学杂志》
CAS
2014年第4期1035-1038,共4页
Molecular Cardiology of China
基金
国家自然科学基金项目(81273909)
