白细胞介素-9在急性脑梗死中的临床意义

Clinical significance of IL-9 in acute cerebral infarction

目的探讨白细胞介素-9(IL-9)在急性脑梗死中的临床意义。方法选择急性脑梗死患者75例(病例组)和健康体检者50名(正常对照组)。采用酶联免疫吸附试验(ELISA)检测两组血清IL-9及C反应蛋白(CRP)水平,比较两组间的差异;另根据脑梗死面积的大小分为小面积梗死组和大面积梗死组,测定两组血清IL-9及CRP水平并进行比较;同时分析IL-9与CRP之间的关系。结果病例组血清IL-9和CRP水平显著高于对照组(P<0.01);大面积梗死组IL-9和CRP水平较小面积梗死组显著升高(P<0.01);血清IL-9与CRP水平呈正相关(r=0.896,P=0.000)。结论 IL-9可能参与了急性脑梗死的发生发展,其机制可能与IL-9介导的炎症反应有关。

Objective To investigate the clinical significance of interleukin-9（ IL-9） in acute cerebral infarction. Methods The serum IL-9 and CRP levels in 75 cases of acute cerebral infarction in the case group and in50 healthy cases in control group were tested by enzyme linked immune sorbent assay（ ELISA）. The differences in IL-9and CRP between two groups,and between the small area cerebral infarction and large area cerebral infarction were compared,and the relationship between IL-9 and CRP was analyzed. Results IL-9 and CRP levels in serum the case group were significantly higher than those in control group（ P〈0. 01）; the serum IL-9 and CRP levels in cases of large area infarction were higher than those in cases of small area infarction（ P〈0. 01）; There was a positive correlation between serum IL-9 and CRP level（ r = 0. 896,P = 0. 000）. Conclusion IL-9 may participate in the occurrence and development of acute cerebral infarction,and its mechanism may be related to the IL-9 mediated inflammatory reaction.