血浆纤维蛋白原与冠状动脉病变的关系研究

Study on the relationship between coronary artery lesions and plasma fibrinogen

目的 探讨血浆纤维蛋白原（Fg）与冠状动脉病变之间的关系。方法 2014年2-4月收治的拟诊稳定型冠心病患者91例,统计其入院基本临床资料,根据冠状动脉造影检查结果分为非冠心病组21例,单支病变组37例,2支病变组16例,3支或左主干病变组17例,均检测Fg、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）。分析血浆纤维蛋白原与冠状动脉病变之间的关系。结果 与非冠心病组比较,2支病变组、3支或左主干病变组Fg水平均升高,比较差异均有统计学意义（P〈0.05）。多因素Logistic回归分析显示：性别（OR=9.72,95%CI 1.56-60.76,P=0.02）、年龄（OR=1.09,95%CI 1.00-1.17,P=0.04）、TC（OR=10.87,95%CI 1.56-76.24,P=0.02）、LDL-C（OR=1.06,95%CI 1.01-1.50,P=0.01）、Fg（OR=7.40,95%CI 1.82-30.03,P=0.01）是冠状动脉病变的危险因素。结论 性别、年龄、TC、LDL-C、Fg是冠状动脉病变的危险因素,冠状动脉病变后Fg水平可升高,尚不能肯定与病变程度有关。

Objectvi e To investigate the relationship between coronary artery lesions and plasma fibrinogen （Fg）. Methods From 2014 February to April , 91 cases of patients with suspected stable coronary artery disease were enrolled , based on the admission of basic clinical data , according to the results of coronary angiography , they were divided into non-cor-onary artery disease group of 21 cases, single vessel disease group of 37 cases, 2 lesions in 16 cases, 3 vessel or left main le-sion group in 17 cases.Fg, total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL -C） were detected .Analyzed the relationship between plasma fibrinogen and coronary ar-tery disease.Results Compared with non-coronary artery disease group ,2-vessel group and 3-vessel or left main lesion group ’ s Fg levels were elevated,the differences were significant （ P〈0 .05）.Multivariate Logistic regression analysis showed：gen-der （OR=9.72, 95%CI 1.56-60.76, P =0.02）, age （OR=1.09, 95%CI 1.00-1.17,P =0.04）, TC （OR=10.87, 95%CI 1.56-762.4 , P =0.02）, LDL-C （OR=1.06, 95%CI 1.01-1.50, P=0 .01）, Fg （OR=74.0 ,95 %CI 1.82-30.03, P =0.01）were risk factors for coronary artery disease .Conclusion Gender, age, TC, LDL-C, Fg are risk factors for coronary artery disease , Fg level was increased in coronary artery disease patients , but the relationship with the severity of disease is not determined yet .