血清Adropin水平与缺血性脑卒中病情严重程度的相关性分析

The relationship between serum adropin levels and disease severity of cerebral ischemic stroke

目的 探讨缺血性脑卒中血清Adropin水平变化及其与病情严重程度的相关性。方法 缺血性卒中患者120例为卒中组,采用美国国立卫生院卒中量表（NIHSS）评估患者病情的严重程度,根据NIHSS评分分为3个亚组：轻度亚组（NIHSS〈4分）44例、中度亚组（NIHSS 4-15分）40例和重度亚组（NIHSS〉15分）36例。另选健康体检者30例作为对照组。采用酶联免疫吸附分析（ELISA）检测血清Adropin水平,全自动生化分析仪检测血清LDL-C、HDL-C、TG及TC水平;采用Pearson检验方法进行血清Adropin水平与NIHSS评分相关性分析。结果 缺血性脑卒中患者血清Adropin、HDL-C水平较对照组明显下降（t=5.976,8.845,P〈0.01）,血清TC、TG及LDL-C均较对照组明显升高（t=10.195,15.331,10.296,P〈0.01）。随着NIHSS评分的升高血清Adropin水平逐渐降低（F=518.547,P〈0.01）。相关分析显示血清Adropin水平与NIHSS评分呈明显负相关（r=-0.958,P=0.000）。结论 血清Adropin变化参与了缺血性脑卒中的发生发展,可以评估缺血性脑卒中患者的临床严重程度。

Objective To investigate the correlation between changes of cerebral ischemic stroke serum Adropin level and the severity of the disease .Methods 120 patients with cerebral ischemic stroke were enrolled , according to the USA Na-tional Institutes of Health Scale （NIHSS） stroke score to assess the severity of the patient＆#39;s condition, patients were divided in-to 3 subgroups：mild sub group （NIHSS〈4） with 44 cases, moderate subgroup （NIHSS 4-15） with 40 cases and severe subgroup （NIHSS〉15） with 36 cases.Another 30 healthy subjects were selected as control group .Adsorption analysis by en-zyme linked immunosorbent assay （ ELISA） to detect the level of serum Adropin , serum LDL-C, HDL-C, TG and TC levels detection were performed by automatic biochemistry analyzer;using Pearson test methods to analyze serum Adropin level and correlation with NIHSS score.Results Compared with the control group, cerebral ischemic stroke patients’ serum Adropin, HDL-C level decreased significantly （ t =5.976, t =8.845, P 〈0.01）, serum TC, TG and LDL-C were obviously higher than control group （ t =10.195, t =15.331, t =10.296, P 〈0.01）.Along with the NIHSS score increased, the serum Adropin levels decreased gradually （ F =518.547, P 〈0.01）.Correlation analysis showed that there was a significant nega-tive correlation of serum Adropin level and NIHSS score （ R =-0.958, P =0.000）.Conclusion Changes of serum Adropin participate in the occurrence and development of ischemic stroke , it can evaluate the clinical severity of patients with ischemic stroke .